ArticleThe Journal of rheumatology2008
Association between crystals and cartilage degeneration in the ankle.
Article in The Journal of rheumatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chondrocalcinosis does not affect functional outcome and prosthesis survival in patients after total or unicompartmental knee arthroplasty: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- The anatomical pathology of gout: a systematic literature review.BMC musculoskeletal disorders · 2019Pooled it
- Trial
- Intraosseous Bone Marrow Concentrate and Long-Term Procedure-Free Survival in Bilateral Non-Traumatic Ankle Osteoarthritis: A Contralateral-Controlled Study.Medicina (Kaunas, Lithuania) · 2026Article
- The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee OA: The Multicenter Osteoarthritis study.Osteoarthritis and cartilage · 2026Observational
- Prevalence and Severity of Spinal Osteoarthritis in Gout Patients Versus Non-Gout Controls.Gout, urate, and crystal deposition disease · 2026Article
- Accelerated Progression of Arthritis after Four-Corner Fusion in Patients with Calcium Pyrophosphate Deposition Disease.Journal of wrist surgery · 2026Article
- Imaging and management of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Gouty tophi in the thoracic spinal canal with incomplete paraplegia: a case report.Frontiers in surgery · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- The pathogenesis of gout.Journal of rheumatic diseases · 2025Review
- Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis.Cartilage · 2024Article
- Unraveling the pathological biomineralization of monosodium urate crystals in gout patients.Communications biology · 2024Article
- Arthroscopic surgery for ankle gouty arthritis: a retrospective analysis of clinical outcomes at six month follow-up based on a novel classification system.International orthopaedics · 2024Article
- Recent advances in the therapeutic management of calcium pyrophosphate deposition disease.Frontiers in medicine · 2024Review
- Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Crystal arthropathies and osteoarthritis-where is the link?Skeletal radiology · 2023Review
- Prevalence of intra-articular mineralization on knee computed tomography: the multicenter osteoarthritis study.Osteoarthritis and cartilage · 2023Article
- Downregulation of Sox8 mediates monosodium urate crystal-induced autophagic impairment of cartilage in gout arthritis.Cell death discovery · 2023Article
- Chondrocalcinosis and Osteoarthritis: A Literature Review.European journal of rheumatology · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveMonosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals have been observed in synovial joints both before and after the onset of osteoarthritis (OA). The relationship between crystals and OA, however, remains controversial. We compared histologic and immunohistochemical patterns in articular cartilage of ankle joints with and without crystals.
methodsA sample of 7,855 human cadaveric tali was examined for the presence of surface and beneath-the-surface crystals. A random subsample of tali with and without crystals underwent crystal analysis by Fourier transform infrared spectroscopy (FTIR), histologic examination, and immunohistochemistry for S100 protein, superficial zone protein, collagen X, cSRC.
resultsThe prevalence of grossly visible crystals in the pool of donors over 18 years of age was 4.7% and correlated with advanced age, male sex, and obesity. Crystals were strongly associated with cartilage lesions and these lesions appeared to be biomechanically induced, being located where opposing articular surfaces might not be in congruence with each other. Thirty-four percent of the random subsamples of crystals upon which FTIR was performed contained CPPD, and the remainder were MSU crystals. Both crystal types were associated with higher levels of superficial zone protein and collagen X.
conclusionWe show that the presence of surface crystals of either MSU or CPPD is strongly correlated with cartilage lesions in the talus. The histologic similarities in cartilage from joints with CPPD crystals compared to those with MSU crystals, together with what is known about the dramatically different etiologic factors producing these crystals, strongly suggest that these lesions are biomechanically induced.
Indexed as
Identifiers
18412302PMC6240447What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.