ArticleGenome research2008
A high-resolution map of nucleosome positioning on a fission yeast centromere.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members.Nucleic acids research · 2020Article
- Article
- Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A)-containing nucleosome positioning in the fission yeast.The Journal of biological chemistry · 2013Article
- Myb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast.The EMBO journal · 2013Article
- Chromatin architectures at fission yeast transcriptional promoters and replication origins.Nucleic acids research · 2012Article
- Neocentromeres and epigenetically inherited features of centromeres.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- NSeq: a multithreaded Java application for finding positioned nucleosomes from sequencing data.Frontiers in genetics · 2012Article
- Integrity of chromatin and replicating DNA in nuclei released from fission yeast by semi-automated grinding in liquid nitrogen.BMC research notes · 2011Article
- Diversity in requirement of genetic and epigenetic factors for centromere function in fungi.Eukaryotic cell · 2011Review
- Absence of positive selection on centromeric histones in Tetrahymena suggests unsuppressed centromere: drive in lineages lacking male meiosis.Journal of molecular evolution · 2011Article
- Heterochromatin is required for normal distribution of Neurospora crassa CenH3.Molecular and cellular biology · 2011Article
- Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.Genes & development · 2010Article
- Genome-wide maps of mononucleosomes and dinucleosomes containing hyperacetylated histones of Aspergillus fumigatus.PloS one · 2010Article
- The coexistence of the nucleosome positioning code with the genetic code on eukaryotic genomes.Nucleic acids research · 2009Article
- Predicting nucleosome positions on the DNA: combining intrinsic sequence preferences and remodeler activities.Nucleic acids research · 2009Article
- Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.Molecular cell · 2009Article
- The impact of the nucleosome code on protein-coding sequence evolution in yeast.PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A key element for defining the centromere identity is the incorporation of a specific histone H3, CENPA, known as Cnp1p in Schizosaccharomyces pombe. Previous studies have suggested that functional S. pombe centromeres lack regularly positioned nucleosomes and may involve chromatin remodeling as a key step of kinetochore assembly. We used tiling microarrays to show that nucleosomes are, in fact, positioned in regular intervals in the core of centromere 2, providing the first high-resolution map of regional centromere chromatin. Nucleosome locations are not disrupted by mutations in kinetochore protein genes cnp1, mis18, mis12, nuf2, mal2; overexpression of cnp1; or the deletion of ams2, which encodes a GATA-like factor participating in CENPA incorporation. Bioinformatics analysis of the centromere sequence indicates certain enriched motifs in linker regions between nucleosomes and reveals a sequence bias in nucleosome positioning. In addition, sequence analysis of nucleosome-free regions identifies novel binding sites of Ams2p. We conclude that centromeric nucleosome positions are stable and may be derived from the underlying DNA sequence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.