ReviewCanadian family physician Medecin de famille canadien2008
Vitamin B12 and health.
Review in Canadian family physician Medecin de famille canadien, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- The Oral Bioavailability of Vitamin BNutrients · 2024Trial
- The Role of Cobalamin in Multiple Sclerosis: An Update.Inflammation · 2025Review
- The Use of Grape By-Products as a Feed Additive Enhances the Oxidative Stability of Rabbit Meat.Veterinary sciences · 2025Article
- Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation.The EPMA journal · 2024Article
- Multifactorial Microvariability of the Italian Raw Milk Cheese Microbiota and Implication for Current Regulatory Scheme.mSystems · 2023Article
- Article
- Vitamin BMolecules (Basel, Switzerland) · 2022Review
- Article
- Vitamin B12 deficiency in a large cohort of healthcare professionals across the network of an eyecare organization in India.Indian journal of ophthalmology · 2022Article
- Review
- Clinically-diagnosed vitamin deficiencies and disorders in the entire United States military population, 1997-2015.Nutrition journal · 2021Article
- The effect of consuming multivitamin/mineral supplements on elderly quality of life: Based on randomized control trial.Journal of education and health promotion · 2021Article
- Burden of Vitamin D, Vitamin B12 and Folic Acid Deficiencies in an Aging, Rural Indian Community.Frontiers in public health · 2021Article
- Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies.Nutrients · 2020Review
- Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study.Journal of medical biochemistry · 2018Article
- Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?Biology · 2015Review
- B-vitamins and bone health--a review of the current evidence.Nutrients · 2015Review
- Glossitis secondary to vitamin B12 deficiency anemia.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Article
- Postural control in patients after a recent vestibular neuritis with hyperhomocysteinemia.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2013Article
- Genetic and environmental influences on nutrient intake.Genes & nutrition · 2013Article
Corrections and comments
- Commented on byVitamin beef.2008
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review recent evidence that suggests vitamin B12 is associated with risk reduction for some chronic diseases and birth defects. QUALITY OF EVIDENCE: A MEDLINE search from 1999 to 2007 was performed using the key word vitamin B12. The most relevant articles (129) dealt with cardiovascular disease, cancer, mental health, and birth outcomes;most studies presented level II evidence. MAIN MESSAGE: Vitamin B12 might confer health benefits; however, such benefits are difficult to ascertain because of the complementary functions of vitamin B12 and folic acid. Vitamin B12 might lower high homocysteine levels below a threshold level achieved by folic acid alone. Furthermore, the interactions between the nutritional environment and genotype might have an important influence on vitamin B12, chronic disease risk, and risk of neural tube defects.
conclusionVitamin B12 might help protect against chronic disease and neural tube defects, but more research, particularly in the area of nutritional genomics, is needed to determine how vitamin B12 might augment the benefits of folic acid. Some consideration should be given to the potential value of fortifying foods with vitamin B12 in addition to the current mandatory folic acid fortification of grains.
Indexed as
Identifiers
18411381PMC2294088W1955662213What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.