How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

29 citing papers in PubMed.

1. Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter.Nature communications · 2026
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2. Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.Nature communications · 2026
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3. Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter.eLife · 2026
   Article
4. Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel.Nature structural & molecular biology · 2025
   Article
5. Kalium 3.0 is a comprehensive depository of natural, artificial, and labeled polypeptides acting on potassium channels.Protein science : a publication of the Protein Society · 2023
   Article
6. Numbers count: How STIM and Orai stoichiometry affect store-operated calcium entry.Cell calcium · 2019
   Review
7. Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener.The Journal of general physiology · 2018
   Article
8. One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.The Journal of general physiology · 2018
   Article
9. Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.The Journal of general physiology · 2018
   Article
10. Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel.Biophysical journal · 2016
    Article
11. IP3 receptors: Take four IP3 to open.Science signaling · 2016
    Article
12. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.The Journal of general physiology · 2015
    Article
13. Store-Operated Calcium Channels.Physiological reviews · 2015
    Review
14. The pain receptor TRPV1 displays agonist-dependent activation stoichiometry.Scientific reports · 2015
    Article
15. The Link between Inactivation and High-Affinity Block of hERG1 Channels.Molecular pharmacology · 2015
    Article
16. Studying macromolecular complex stoichiometries by peptide-based mass spectrometry.Proteomics · 2015
    Review
17. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243.Molecular pharmacology · 2015
    Article
18. Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels.The Journal of physiology · 2014
    Article
19. Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.The Journal of biological chemistry · 2014
    Article
20. Stoichiometry of altered hERG1 channel gating by small molecule activators.The Journal of general physiology · 2014
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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