ArticleAntimicrobial agents and chemotherapy2008
Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Antibiotics for treatment of leptospirosis.The Cochrane database of systematic reviews · 2024Pooled it
- Antibiotics for leptospirosis.The Cochrane database of systematic reviews · 2012Pooled it
- Review
- Review
- Biofilm formationHeliyon · 2023Article
- Evaluation by polymerase chain reaction assay of persistent shedding of pathogenic leptospires in the urine of dogs with leptospirosis.Journal of veterinary internal medicine · 2022Article
- Complete Genome Sequencing ofPathogens (Basel, Switzerland) · 2021Article
- In Vitro Anti-Leptospiral Activity ofInternational journal of environmental research and public health · 2021Article
- Insight into the Epidemiology of Leptospirosis: A Review ofAnimals : an open access journal from MDPI · 2021Review
- Article
- Bacteriostatic and Bactericidal Effect of Tigecycline onAntibiotics (Basel, Switzerland) · 2020Article
- Antimicrobial Susceptibility Testing ofThe American journal of tropical medicine and hygiene · 2019Article
- Doxycycline Attenuates Leptospira-Induced IL-1β by Suppressing NLRP3 Inflammasome Priming.Frontiers in immunology · 2017Article
- Hypoxemic Respiratory Failure from Acute Respiratory Distress Syndrome Secondary to Leptospirosis.Case reports in critical care · 2017Article
- Comparative analyses of transport proteins encoded within the genomes of Leptospira species.Microbial pathogenesis · 2016Article
- Profiling of Leptospira interrogans, L. santarosai, L. meyeri and L. borgpetersenii by SE-AFLP, PFGE and susceptibility testing--a continuous attempt at species and serovar differentiation.Emerging microbes & infections · 2016Article
- Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species.Microbial pathogenesis · 2015Article
- Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.The American journal of tropical medicine and hygiene · 2015Article
- Leptospirosis in humans.Current topics in microbiology and immunology · 2015Review
- Antibiotic Efficacy in Eliminating Leptospiruria in California Sea Lions (Aquatic mammals · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although antimicrobial therapy of leptospirosis has been studied in a few randomized controlled clinical studies, those studies were limited to specific regions of the world and few have characterized infecting strains. A broth microdilution technique for the assessment of antibiotic susceptibility has been developed at Brooke Army Medical Center. In the present study, we assessed the susceptibilities of 13 Leptospira isolates (including recent clinical isolates) from Egypt, Thailand, Nicaragua, and Hawaii to 13 antimicrobial agents. Ampicillin, cefepime, azithromycin, and clarithromycin were found to have MICs below the lower limit of detection (0.016 microg/ml). Cefotaxime, ceftriaxone, imipenem-cilastatin, penicillin G, moxifloxacin, ciprofloxacin, and levofloxacin had MIC(90)s between 0.030 and 0.125 microg/ml. Doxycycline and tetracycline had the highest MIC(90)s: 2 and 4 microg/ml, respectively. Doxycycline and tetracycline were noted to have slightly higher MICs against isolates from Egypt than against strains from Thailand or Hawaii; otherwise, the susceptibility patterns were similar. There appears to be possible variability in susceptibility to some antimicrobial agents among strains, suggesting that more extensive testing to look for geographic variability should be pursued.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.