ArticleInfection and immunity2008
Protective effect of an extract from Ascaris suum in experimental arthritis models.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- The human immunome in the post-schistosomiasis mass drug administration era.PLoS neglected tropical diseases · 2026Review
- Antiarthritic and Antinociceptive Properties of Ylang-Ylang (Current issues in molecular biology · 2024Article
- Microbes, helminths, and rheumatic diseases.Best practice & research. Clinical rheumatology · 2020Review
- Body fluid from the parasitic worm Ascaris suum inhibits broad-acting pro-inflammatory programs in dendritic cells.Immunology · 2020Article
- Crude extract from Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz leaves decreased intra articular inflammation induced by zymosan in rats.BMC complementary and alternative medicine · 2019Article
- STAT6 and IL-10 are required for the anti-arthritic effects of Schistosoma mansoni via different mechanisms.Clinical and experimental immunology · 2019Article
- Article
- Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond.The American journal of tropical medicine and hygiene · 2016Review
- Parasitic infection as a potential therapeutic tool against rheumatoid arthritis.Experimental and therapeutic medicine · 2016Article
- Immuno-Modulatory Effect and Therapeutic Potential of Brugia malayi Cystatin in Experimentally Induced Arthritis.Indian journal of clinical biochemistry : IJCB · 2016Article
- Vitamin D levels in juvenile idiopathic arthritis from an equatorial region.Rheumatology international · 2015Article
- Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production.Arthritis research & therapy · 2015Article
- Helminthes and insects: maladies or therapies.Parasitology research · 2015Review
- Immunomodulation of liver injury by Ascaris suum extract in an experimental model of autoimmune hepatitis.Parasitology research · 2014Article
- Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis.Clinical and experimental immunology · 2014Review
- Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum.PLoS neglected tropical diseases · 2014Article
- Helminth parasites alter protection against Plasmodium infection.BioMed research international · 2014Review
- The hygiene theory harnessing helminths and their ova to treat autoimmunity.Clinical reviews in allergy & immunology · 2013Review
- Anti-inflammatory and immunomodulatory effect of an extract of Coccidioides posadasii in experimental arthritis.Mycopathologia · 2013Article
- Autoimmunity: Will worms cure rheumatoid arthritis?Nature reviews. Rheumatology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced arthritis (ZYA) or collagen-induced arthritis (CIA). Rats and mice, respectively, received 1 mg and 0.1 mg zymosan intra-articularly (i.a.). Test groups received an A. suum extract either per os (p.o.) or intraperitoneally (i.p.) 30 min prior to i.a. zymosan. Controls received saline. Hypernociception was measured using the articular incapacitation test. Cell influx, nitrite, and cytokine levels were assessed in joint exudates. The synovia and distal femoral extremities were used for histopathology. Cartilage damage was assessed through determining glycosaminoglycan (GAG) content. DBA/1J mice were subjected to CIA. The test group received A. suum extract i.p. 1 day after CIA became clinically detectable. Clinical severity and hypernociception were assessed daily. Neutrophil influx was determined using myeloperoxidase activity. The A. suum extract, either i.p. or p.o., significantly and dose-dependently inhibited cell influx and hypernociception in ZYA in addition to reducing GAG loss and ameliorating synovitis. The A. suum extract reduced i.a. levels of NO, interleukin-1beta (IL-1beta), and IL-10 but not tumor necrosis factor alpha (TNF-alpha) in rats subjected to ZYA while reducing i.a. IL-10, but not IL-1beta or TNF-alpha, levels in mice. Clinically, mice subjected to CIA treated with the A. suum extract had less severe arthritis. Hypernociception, myeloperoxidase activity, and synovitis severity were significantly reduced. These data show that a helminth extract given p.o. protects from arthritis severity in two classical arthritis models. This A. suum effect is species independent and functions orally and parenterally. The results show clinical and structural benefits when A. suum extract is given either prophylactically or therapeutically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.