ArticleThe Journal of biological chemistry2008
Control of the timing of promoter escape and RNA catalysis by the transcription factor IIb fingertip.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Displacement of the transcription factor B reader domain during transcription initiation.Nucleic acids research · 2018Article
- The essential and multifunctional TFIIH complex.Protein science : a publication of the Protein Society · 2018Review
- Article
- RNA polymerase II transcription: structure and mechanism.Biochimica et biophysica acta · 2013Review
- Promoter clearance by RNA polymerase II.Biochimica et biophysica acta · 2013Review
- Evidence that RNA polymerase II and not TFIIB is responsible for the difference in transcription initiation patterns between Saccharomyces cerevisiae and Schizosaccharomyces pombe.Nucleic acids research · 2012Article
- Architecture of the yeast RNA polymerase II open complex and regulation of activity by TFIIF.Molecular and cellular biology · 2012Article
- Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I.Science (New York, N.Y.) · 2011Article
- A concise review on epigenetic regulation: insight into molecular mechanisms.International journal of molecular sciences · 2011Review
- The TFIIB tip domain couples transcription initiation to events involved in RNA processing.The Journal of biological chemistry · 2010Article
- Multiple roles of the RNA polymerase {beta}' SW2 region in transcription initiation, promoter escape, and RNA elongation.Nucleic acids research · 2010Article
- Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.Science (New York, N.Y.) · 2010Article
- Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.The Journal of biological chemistry · 2009Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transcription factor IIB (TFIIB) recruits RNA polymerase II to promoters and inserts a finger domain into its active site, with unknown consequences. Here we show that that the tip of this finger is important for two transcription initiation functions. First, TFIIB acts as a catalytic cofactor for initial RNA bond formation. It does so via a pair of fingertip aspartates that can bind magnesium, placing TFIIB within a family of proteins that insert finger domains to alter the catalytic functions of RNA polymerase. Second, the TFIIB fingertip mediates the timing of the release of TFIIB that is associated with appropriate promoter escape. These initiation requirements may assist in RNA quality control by minimizing functional synthesis when RNA polymerase becomes inappropriately associated with the genome without having been recruited there by TFIIB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.