ArticleThe Journal of biological chemistry2008
Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Distinct interactors define the p63 transcriptional signature in epithelial development or cancer.The Biochemical journal · 2022Article
- p63-related signaling at a glance.Journal of cell science · 2020Review
- Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.Molecular cancer research : MCR · 2020Article
- Radioprotective efficacy of dieckol against gamma radiation-induced cellular damage in hepatocyte cells.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Hepatic p63 regulates steatosis via IKKβ/ER stress.Nature communications · 2017Article
- The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System.International journal of molecular sciences · 2016Review
- Regulation of p63 protein stability via ubiquitin-proteasome pathway.BioMed research international · 2014Review
- IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity.The Journal of biological chemistry · 2013Article
- p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.Nature reviews. Cancer · 2013Review
- p63 the guardian of human reproduction.Cell cycle (Georgetown, Tex.) · 2012Review
- Article
- Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.EMBO reports · 2010Article
- TAp63 is a transcriptional target of NF-kappaB.Journal of cellular biochemistry · 2010Article
- TAp63 induces senescence and suppresses tumorigenesis in vivo.Nature cell biology · 2009Article
- Article
- Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Post-translational modification of the p53 family members is key to their regulation. Here we report the phosphorylation of TAp63gamma, but not DeltaNp63gamma, by IkappaB kinase beta (IKKbeta). Activation of IKKbeta by gamma radiation or tumor necrosis factor-alpha led to increased TAp63gamma protein levels in cells. IKKbeta, but not its kinase-defective mutant IKKbeta-K44A, led to this observed stabilization of TAp63gamma. This stabilization of TAp63gamma in response to gamma radiation was significantly decreased in the absence of IKKbeta. Phosphorylation of TAp63gamma blocks ubiquitylation and possible degradation of this protein. We postulate that phosphorylation of TAp63gamma by IKKbeta stabilizes the TAp63gamma protein by blocking ubiquitylation-dependent degradation of this protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.