ArticleThe Journal of pediatrics2008
Insulin resistance, hyperinsulinemia, and energy intake in overweight children.
Article in The Journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of metformin on energy intake and satiety in obese children.Diabetes, obesity & metabolism · 2015Trial
- Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.Diabetes · 2011 · on this mapTrial
- The Cerebellar Response to Visual Portion Size Cues Is Associated with the Portion Size Effect in Children.Nutrients · 2024Article
- Are caveolin-1 minor alleles more likely to be risk alleles in insulin resistance mechanisms in metabolic diseases?BMC research notes · 2021Article
- Bidirectional temporal relationship between obesity and hyperinsulinemia: longitudinal observation from a Chinese cohort.BMJ open diabetes research & care · 2021Article
- A longitudinal study of serum insulin and insulin resistance as predictors of weight and body fat gain in African American and Caucasian children.International journal of obesity (2005) · 2017Article
- Article
- Assessment of metformin as an additional treatment to therapeutic lifestyle changes in pediatric patients with metabolic syndrome.Cholesterol · 2012Article
- Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech adult population.Genes & nutrition · 2009Article
- Relationships between reported macronutrient intake and insulin dynamics in a multi-ethnic cohort of early pubertal children.International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity · 2009Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the relationship between energy intake during a buffet meal and indexes of insulin dynamics in overweight children. STUDY
designNinety-five nondiabetic, overweight (body mass index > or = 95th percentile) children (age 10.3 +/- 1.4 years) selected lunch from a 9835-kcal buffet eaten ad libitum after an overnight fast. The associations between energy intake and measures of insulin dynamics, in the postabsorptive state and during a 2-hour hyperglycemic clamp, were determined. Covariates in the statistical model included race, sex, skeletal age, fat-free mass, fat mass, socioeconomic status, and number of foods in the buffet rated as acceptable.
resultsEnergy intake was positively associated with the fasting homeostasis model assessment for insulin resistance index (beta = 0.24, P = .042), fasting insulin/glucose ratio (beta = 0.24, P = .044), first-phase insulin (beta = 0.23, P = .032), and first-phase C-peptide (beta = 0.21, P = .046); energy intake was negatively associated with clamp-derived insulin sensitivity (beta = -0.29, P = .042). Each 10% decrease in clamp-derived insulin sensitivity predicted a 27-kcal greater energy intake.
conclusionsInsulin resistance and hyperinsulinemia are associated with greater energy intake after an overnight fast in overweight children. These associations suggest mechanisms whereby insulin resistance may contribute to excessive weight gain in children.
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