ArticleThe British journal of dermatology2008
Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.
Article in The British journal of dermatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Sex-specific developmental trajectories of eczema from infancy to age 26 years: A birth cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study.Respiratory research · 2019Article
- Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.Frontiers in genetics · 2019Article
- Effect of gestational oily fish intake on the risk of allergy in children may be influenced byGenes & nutrition · 2019Article
- Cohort Profile: The Isle Of Wight Whole Population Birth Cohort (IOWBC).International journal of epidemiology · 2018Observational
- Changes in DNA Methylation from Age 18 to Pregnancy in Type 1, 2, and 17 T Helper and Regulatory T-Cells Pathway Genes.International journal of molecular sciences · 2018Article
- DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence.Vaccine · 2016Article
- Article
- Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis.International journal of molecular sciences · 2016Review
- Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation.Clinical epigenetics · 2015Article
- Atopic dermatitis patients carrying G allele in -1082 G/A IL-10 polymorphism are predisposed to higher serum concentration of IL-10.Archives of medical science : AMS · 2014Article
- Molecular biology of atopic dermatitis.Clinical reviews in allergy & immunology · 2014Review
- Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier?International archives of allergy and immunology · 2014Article
- Article
- Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study.BMC medical genetics · 2013Article
- DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants.Journal of the European Academy of Dermatology and Venereology : JEADV · 2013Article
- Functional characterisation of the bovine neuropeptide Y gene promoter and evaluation of the transcriptional activities of promoter haplotypes.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAtopic eczema is characterized by Th2-dominant immunity with the cytokine interleukin 13 and the transcription factor GATA binding protein 3 playing a critical role.
objectivesWe assessed the association of polymorphisms in the IL13 and GATA3 genes with childhood eczema.
methodsA birth cohort (n = 1456) was established on the Isle of Wight in 1989 and followed at the ages of 1 (n = 1167), 2 (n = 1174), 4 (n = 1218) and 10 years (n = 1373) to determine the prevalence of allergic disease including eczema. At 4 and 10 years, skin prick testing was performed. Whole blood samples (n = 923) were obtained at the 10-year assessment, stored frozen, and genotyped. Five polymorphisms from IL13 and seven from GATA3 were genotyped for this analysis. Repeated measurement analyses were conducted for the occurrence of eczema at ages 1, 2, 4 and 10 years. All analyses were adjusted for maternal and paternal eczema, low birth weight (< 2500 g), breastfeeding >or= 3 months and age.
resultsIL13 was not associated with childhood eczema. For GATA3, the single nucleotide polymorphism (SNP) rs2275806 (promoter region) showed an increased odds ratio for atopic eczema independent of whether the comparison group had a positive skin prick test. The SNP rs444762 (intron 3 region) was associated with atopic eczema in comparison with children without eczema. The increased relative risks remained significant after adjustment for multiple testing only for rs2275806 (P < 0.05).
conclusionsA SNP in GATA3 is associated with atopic eczema. This finding highlights the importance of GATA3 as an immune-modulating gene in atopic eczema.
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