ArticleJournal of medicinal chemistry2008
Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.
Article in Journal of medicinal chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Central somatostatin signaling and regulation of food intake.Annals of the New York Academy of Sciences · 2019Review
- Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response.Frontiers in neuroscience · 2017Review
- The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.Hormones and behavior · 2015Review
- Article
- Brain somatostatin receptor 2 mediates the dipsogenic effect of central somatostatin and cortistatin in rats: role in drinking behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats.Neuroscience letters · 2014Article
- Orexigenic response to tail pinch: role of brain NPY(1) and corticotropin releasing factor receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Prospective of ⁶⁸Ga-radiopharmaceutical development.Theranostics · 2013Review
- Modulation of the adaptive response to stress by brain activation of selective somatostatin receptor subtypes.Peptides · 2013Review
- Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes.Current pharmaceutical design · 2013Review
- Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications.Frontiers in endocrinology · 2012Article
- Central administration of pan-somatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in rats.Neurogastroenterology and motility · 2011Article
- Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice.Neurogastroenterology and motility · 2011Article
- Chronic injection of pansomatostatin agonist ODT8-SST differentially modulates food intake and decreases body weight gain in lean and diet-induced obese rats.Regulatory peptides · 2011Article
- Activation of brain somatostatin 2 receptors stimulates feeding in mice: analysis of food intake microstructure.Physiology & behavior · 2010Article
- Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in rats.Brain research · 2010Article
- Article
- Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.Biopolymers · 2008Article
- Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.Journal of medicinal chemistry · 2008Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The synthesis, biological testing, and NMR studies of several analogues of H-c[Cys (3)-Phe (6)-Phe (7)-DTrp (8)-Lys (9)-Thr (10)-Phe (11)-Cys (14)]-OH (ODT-8, a pan-somatostatin analogue, 1) have been performed to assess the effect of changing the stereochemistry and the number of atoms in the disulfide bridge on binding affinity. Cysteine at positions 3 and/or 14 (somatostatin numbering) were/was substituted with d-cysteine, norcysteine, D-norcysteine, homocysteine, and/or D-homocysteine. The 3D structure analysis of selected partially selective, bioactive analogues (3, 18, 19, and 21) was carried out in dimethylsulfoxide. Interestingly and not unexpectedly, the 3D structures of these analogues comprised the pharmacophore for which the analogues had the highest binding affinities (i.e., sst 4 in all cases).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.