Evidence map›Paper›PMID 18408986›Full record

Trial reportLasers in medical science2009

Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation.

Nasrin Zand, Leila Ataie-Fashtami, Gholamreza Esmaeeli Djavid, Mohsen Fateh, Mohammad-Reza Alinaghizadeh, Seyyed-Mostafa Fatemi, Fateme Arbabi-Kalati

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. [Low-level laser therapy for the treatment of male infertility and erectile dysfunction].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Experimental Therapeutic Solutions for Behcet's Disease.Journal of experimental pharmacology · 2021
    Review
  13. Article
  14. Review
  15. The Immediate Pain-Relieving Effects of Non-Thermal COJournal of lasers in medical sciences · 2020
    Article
  16. Article
  17. Review
  18. Review
  19. Different Therapeutic Effects of COFrontiers in neurology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nasrin ZandIranian Center for Medical Laser (ICML), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran. zand_nas@yahoo.com
Leila Ataie-Fashtami
Gholamreza Esmaeeli Djavid
Mohsen Fateh
Mohammad-Reza Alinaghizadeh
Seyyed-Mostafa Fatemi
Fateme Arbabi-Kalati
Academic Center for Education, Culture and Research · IRTabriz University of Medical Sciences · IRUniversity of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This randomized controlled clinical trial was designed to evaluate the efficacy of single-session, non-thermal, carbon dioxide (CO(2)) laser irradiation in relieving the pain of minor recurrent aphthous stomatitis (miRAS) as a prototype of painful oral ulcers. Fifteen patients, each with two discrete aphthous ulcers, were included. One of the ulcers was randomly allocated to be treated with CO(2) laser (1 W of power in de-focused continuous mode) and the other one served as a placebo. Before laser irradiation, a layer of transparent, non-anesthetic gel was placed on both the laser lesions and the placebo lesions. The patients were requested to grade their pain on a visual analog scale up to 96 h post-operatively. The reduction in pain scores was significantly greater in the laser group than in the placebo group. The procedure itself was not painful, so anesthesia was not required. Powermetry revealed the CO(2) laser power to be 2-5 mW after passing through the gel, which caused no significant temperature rise or any visual effect of damage to the oral mucosa. Our results showed that a low-intensity, non-thermal, single-session of CO(2) laser irradiation reduced pain in miRAS immediately and dramatically, with no visible side effects.

Indexed as

Low-Level Light TherapyAdultFemaleHumansLasers, GasMaleMiddle AgedPainRecurrenceStomatitis, AphthousYoung Adult

Identifiers

PMID18408986
OpenAlexW2062450427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.