ArticleDementia and geriatric cognitive disorders2008
Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.
Article in Dementia and geriatric cognitive disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome.JAMA network open · 2022Pooled it
- Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer's disease.BMC systems biology · 2013Pooled it
- Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome.Brain communications · 2023Article
- The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.Journal of clinical medicine · 2021Review
- Alzheimer-Related Cerebrovascular Disease in Down Syndrome.Annals of neurology · 2020Article
- Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary.International journal of developmental disabilities · 2020Article
- Epidemiology of estrogen and dementia in women with Down syndrome.Free radical biology & medicine · 2018Review
- Polymorphisms in sex steroid receptors: From gene sequence to behavior.Frontiers in neuroendocrinology · 2017Review
- Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome.Biochimica et biophysica acta · 2016Review
- Psychiatric disorders in adolescents and young adults with Down syndrome and other intellectual disabilities.Journal of neurodevelopmental disorders · 2015Article
- Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration.Brain research bulletin · 2014Review
- A pilot study of the association between genetic polymorphisms involved in estrogen signaling and infant male genital phenotypes.Asian journal of andrology · 2012Article
- Association of estrogen receptor α gene PvuII and XbaI polymorphisms with non-small cell lung cancer.Oncology letters · 2012Article
- Microarray analysis on human neuroblastoma cells exposed to aluminum, β(1-42)-amyloid or the β(1-42)-amyloid aluminum complex.PloS one · 2011Article
- Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.Dementia and geriatric cognitive disorders · 2011Article
- EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP.FEBS letters · 2010Article
- Hormonal influences on cognition and risk for Alzheimer's disease.Current neurology and neuroscience reports · 2010Review
- Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin.The Journal of biological chemistry · 2010Article
- Protective actions of sex steroid hormones in Alzheimer's disease.Frontiers in neuroendocrinology · 2009Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGenetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD.
methodsWe examined the relation of polymorphisms in ESR1 to the risk of AD in women with Down syndrome. The subjects (181 women with DS, 41-78 years of age) were followed at 14- to 18-month intervals. Information from cognitive assessments, caregiver interviews, medical record reviews and neurological examinations was used to classify dementia. Genomic DNA was genotyped for 5 single-nucleotide polymorphisms in the upstream region and the first exon/intron of the ESR1 gene. Their association with dementia risk was evaluated, adjusting for covariates.
resultsWomen with at least 1 copy of the C allele at rs2234693 (PvuII) and those homozygous for the C allele at rs2077647 had an almost 3-fold increase in the risk of AD, compared with women without the C allele. The increased risks were independent of the apolipoprotein E genotype.
conclusionThese findings support a role for estrogen receptor activity in the development of AD in women with Down syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.