ReviewSchizophrenia bulletin2008
Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
Review in Schizophrenia bulletin, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.Journal of psychiatry & neuroscience : JPN · 2013Pooled it
- Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2012Pooled it
- The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia.Schizophrenia bulletin · 2026Article
- Machine learning-based morphological brain analysis in schizophrenia and unaffected siblings: a multisite study of potential risk markers.Frontiers in neuroscience · 2026Article
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Altered Cerebral Curvature in Preterm Infants Is Associated with the Common Genetic Variation Related to Autism Spectrum Disorder and Lipid Metabolism.Journal of clinical medicine · 2022Article
- Heritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families.Psychological medicine · 2022Article
- Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia.Schizophrenia bulletin · 2019Article
- Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders.Neuron · 2018Review
- Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2016Article
- Neurobiology of rodent self-grooming and its value for translational neuroscience.Nature reviews. Neuroscience · 2016Review
- Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives.Schizophrenia research · 2016Article
- Are Autistic Traits in the General Population Related to Global and Regional Brain Differences?Journal of autism and developmental disorders · 2015Article
- Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2015Article
- Neuroimaging Biomarkers for Psychosis.Current behavioral neuroscience reports · 2015Article
- Article
- Disease and genetic contributions toward local tissue volume disturbances in schizophrenia: a tensor-based morphometry study.Human brain mapping · 2012Article
- Boundaries of the psychosis phenotype.Schizophrenia bulletin · 2012Article
- Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest functional impairments associated with schizophrenia have been proposed as endophenotypes. However, few studies have examined the structural variations in the brain that might underlie the functional impairments as useful endophenotypes for schizophrenia. Over the past three decades, there has been an impressive body of literature supporting brain structural alterations in schizophrenia. We critically reviewed the extant literature on the neuroanatomical variations in schizophrenia in this paper to evaluate their candidacy as endophenotypes and how useful they are in furthering the understanding of etiology and pathophysiology of schizophrenia. Brain morphometric measures meet many of the criteria set by different investigators, such as being robustly associated with schizophrenia, heritable, quantifiable, and present in unaffected family members more frequently than in the general population. We conclude that the brain morphometric alterations appear largely to meet the criteria for endophenotypes in psychotic disorders. Some caveats for the utility of endophenotypes are discussed. A proposal to combine more than one endophenotype ("extended endophenotype") is suggested. Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.