ArticleAmerican journal of physiology. Heart and circulatory physiology2008
Mathematical model of the neonatal mouse ventricular action potential.
Article in American journal of physiology. Heart and circulatory physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms.The Journal of general physiology · 2022Article
- Bifurcations and Proarrhythmic Behaviors in Cardiac Electrical Excitations.Biomolecules · 2022Review
- A Mathematical Model for Electrical Activity in Pig Atrial Tissue.Frontiers in physiology · 2022Article
- Pulsed low-energy stimulation initiates electric turbulence in cardiac tissue.PLoS computational biology · 2021Article
- Mechanisms of phase-3 early afterdepolarizations and triggered activities in ventricular myocyte models.Physiological reports · 2021Article
- Calcium-dependent inactivation controls cardiac L-type CaThe Journal of general physiology · 2019Article
- Complex restitution behavior and reentry in a cardiac tissue model for neonatal mice.Physiological reports · 2017Article
- Modeling dynamics in diseased cardiac tissue: Impact of model choice.Chaos (Woodbury, N.Y.) · 2017Article
- Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells.PLoS computational biology · 2016Article
- Myofibroblasts Electrotonically Coupled to Cardiomyocytes Alter Conduction: Insights at the Cellular Level from a DetailedFrontiers in physiology · 2016Article
- A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.The Journal of physiology · 2014Article
- Cellular cardiac electrophysiology modeling with Chaste and CellML.Frontiers in physiology · 2014Article
- Quantitative study of the effect of tissue microstructure on contraction in a computational model of rat left ventricle.PloS one · 2014Article
- The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium.American journal of physiology. Heart and circulatory physiology · 2013Article
- How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.The Journal of physiology · 2012Article
- Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy.Journal of molecular and cellular cardiology · 2012Article
- At the heart of computational modelling.The Journal of physiology · 2012Review
- Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.Stem cell research · 2012Article
- An introduction to dynamical systems.Science signaling · 2011Article
- Getting heart cells on the same wavelength: infrared triggering of Ca2+ transients in cardiac myocytes.The Journal of physiology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Therapies for heart disease are based largely on our understanding of the adult myocardium. The dramatic differences in action potential (AP) shape between neonatal and adult cardiac myocytes, however, indicate that a different set of molecular interactions in neonatal myocytes necessitates different treatment for newborns. Computational modeling is useful for synthesizing data to determine how interactions between components lead to systems-level behavior, but this technique has not been used extensively to study neonatal heart cell function. We created a mathematical model of the neonatal (day 1) mouse myocyte by modifying, on the basis of experimental data, the densities and/or formulations of ion transport mechanisms in an adult cell model. The new model reproduces the characteristic AP shape of neonatal cells, with a brief plateau phase and longer duration than the adult (action potential duration at 80% repolarization = 60.1 vs. 12.6 ms). The simulation results are consistent with experimental data, including 1) decreased density and altered inactivation of transient outward K+ currents, 2) increased delayed rectifier K+ currents, 3) Ca2+ entry through T-type as well as L-type Ca2+ channels, 4) increased Ca2+ influx through Na+/Ca2+ exchange, and 5) Ca2+ transients resulting from transmembrane Ca2+ entry rather than release from the sarcoplasmic reticulum (SR). Simulations performed with the model generated novel predictions, including increased SR Ca2+ leak and elevated intracellular Na+ concentration in neonatal compared with adult myocytes. This new model can therefore be used for testing hypotheses and obtaining a better quantitative understanding of differences between neonatal and adult physiology.
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