ArticleJournal of the American Chemical Society2008
Fluidic and air-stable supported lipid bilayer and cell-mimicking microarrays.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 83 citations in OpenAlex.
- The Molecular Interplay Between Lipids, Cholesterol and Membrane Hydration Layer.Sub-cellular biochemistry · 2026Review
- Hybrid bilayer membranes as platforms for biomimicry and catalysis.Nature reviews. Chemistry · 2022Review
- Nanoarchitectured air-stable supported lipid bilayer incorporating sucrose-bicelle complex system.Nano convergence · 2022Article
- Influenza A virus hemagglutinin prevents extensive membrane damage upon dehydration.BBA advances · 2022Article
- Hydration Layer of Only a Few Molecules Controls Lipid Mobility in Biomimetic Membranes.Journal of the American Chemical Society · 2021Article
- Lipid-Bicelle-Coated Microfluidics for Intracellular Delivery with Reduced Fouling.ACS applied materials & interfaces · 2020Article
- Reversible Self-Assembled Monolayers (rSAMs): Adaptable Surfaces for Enhanced Multivalent Interactions and Ultrasensitive Virus Detection.ACS central science · 2017Article
- Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors.ACS chemical biology · 2014Article
- Engineering lipid bilayer membranes for protein studies.International journal of molecular sciences · 2013Review
- Review
- Latest developments in experimental and computational approaches to characterize protein-lipid interactions.Proteomics · 2012Review
- Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells.Nature protocols · 2012Article
- Air-stable supported membranes for single-cell cytometry on PDMS microchips.Lab on a chip · 2010Article
- Quantitative glycomics from fluidic glycan microarrays.Journal of the American Chemical Society · 2009Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
As drug delivery, therapy, and medical imaging are becoming increasingly cell-specific, there is a critical need for high fidelity and high-throughput screening methods for cell surface interactions. Cell membrane-mimicking surfaces, i.e., supported lipid bilayers (SLBs), are currently not sufficiently robust to meet this need. Here we describe a method of forming fluidic and air-stable SLBs through tethered and dispersed cholesterol groups incorporated into the bottom leaflet. Achieving air stability allows us to easily fabricate SLB microarrays from direct robotic spotting of vesicle solutions. We demonstrate their application as cell membrane-mimicking microarrays by reconstituting peripheral as well as integral membrane components that can be recognized by their respective targets. These demonstrations establish the viability of the fluidic and air-stable SLB platform for generating content microarrays in high throughput studies, e.g., the screening of drugs and nanomedicine targeting cell surface receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.