ArticleWorld journal of gastroenterology2008
Endoscopic diagnosis of gastrointestinal graft-versus-host disease.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01583712 (Diagnosis of Acute Gastrointestinal Graft-versus-Host Disease by Early Endomicroscopic Features of the Small Intestine), which is not on this map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnosis of Acute Gastrointestinal Graft-versus-Host Disease by Early Endomicroscopic Features of the Small Intestine
Who cites it
13 citing papers in PubMed.
- Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma.Cancer immunity · 2010Trial
- Impact of the histologic grade of acute gastrointestinal graft-versus-host disease on outcomes in pediatric patients treated with allogeneic hematopoietic stem cell transplantation.Frontiers in medicine · 2023Article
- Assessing the yield and safety of endoscopy in acute graft-World journal of gastrointestinal endoscopy · 2020Article
- Upper gastrointestinal acute graft-Haematologica · 2018Article
- Acute graft-versus-host disease of the gut: considerations for the gastroenterologist.Nature reviews. Gastroenterology & hepatology · 2017Review
- Stepwise Endoscopy Based on Sigmoidoscopy in Evaluating Pediatric Graft-versus-Host Disease.Pediatric gastroenterology, hepatology & nutrition · 2016Article
- The Diagnostic Yield of Site and Symptom-Based Biopsies for Acute Gastrointestinal Graft-Versus-Host Disease: A 5-Year Retrospective Review.Digestive diseases and sciences · 2016Article
- Immunological basis for treatment of graft versus host disease after liver transplant.Expert review of clinical immunology · 2016Review
- Esophageal stenosis with sloughing esophagitis: A curious manifestation of graft-vs-host disease.World journal of gastroenterology · 2015Article
- Fulminant gastrointestinal graft-versus-host disease concomitant with cytomegalovirus infection: case report and literature review.World journal of gastroenterology · 2013Review
- Endoscopic diagnosis of acute intestinal GVHD following allogeneic hematopoietic SCT: a retrospective analysis in 175 patients.Bone marrow transplantation · 2012Article
- Graft Versus Host Diseases Presenting Endoscopically as a Tubular Structure Mimicking a Worm.Gastroenterology research · 2009Article
- Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the diagnostic value of endoscopy in patients with gastrointestinal graft-versus-host disease (GI GVHD).
methodsWe identified 8 patients with GI GVHD following allogeneic hematopoietic stem cell trans-plantation (HSCT). GVHD was defined histologically as the presence of gland apoptosis, not explained by other inflammatory or infectious etiologies.
resultsThe symptoms of GI GVHD included anorexia, nausea, vomiting, watery diarrhea, abdominal pain, GI bleeding, etc. Upper endoscopic appearance varied from subtle mucosal edema, hyperemia, erythema to obvious erosion. Colonoscopic examination showed diffuse edema, hyperemia, patchy erosion, scattered ulcer, sloughing and active bleeding. Histological changes in GI GVHD included apoptosis of crypt epithelial cells, dropout of crypts, and lymphocytic infiltration in epithelium and lamina propria. The involvement of stomach and rectocolon varied from diffuse to focal.
conclusionEndoscopy may play a significant role in early diagnosis of GI GVHD patients following allogeneic HSCT, and histologic examination of gastrointestinal biopsies is needed to confirm the final diagnosis.
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Registered trials
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