ArticleMolecular and cellular neurosciences2008
Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex.
Article in Molecular and cellular neurosciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Nonmalignant Features Associated with Inherited Colorectal Cancer Syndromes-Clues for Diagnosis.Cancers · 2022Review
- An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors.Molecules (Basel, Switzerland) · 2021Review
- 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons.PloS one · 2021Article
- Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function.Hereditary cancer in clinical practice · 2020Article
- IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.Molecular biology of the cell · 2019Article
- Mechanism of IRSp53 inhibition by 14-3-3.Nature communications · 2019Article
- Synaptic NNature neuroscience · 2018Article
- Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors.Frontiers in synaptic neuroscience · 2018Article
- Identification of Novel 14-3-3 Residues That Are Critical for Isoform-specific Interaction with GluN2C to Regulate N-Methyl-D-aspartate (NMDA) Receptor Trafficking.The Journal of biological chemistry · 2015Article
- Looking below the surface of nicotinic acetylcholine receptors.Trends in pharmacological sciences · 2015Review
- Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Inference of Evolutionary Forces Acting on Human Biological Pathways.Genome biology and evolution · 2015Article
- Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.Molecular psychiatry · 2014Article
- Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC).PloS one · 2014Article
- Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels.Channels (Austin, Tex.) · 2014Article
- Article
- Neuroligin 2 is expressed in synapses established by cholinergic cells in the mouse brain.PloS one · 2013Article
- Wnt signaling in neuromuscular junction development.Cold Spring Harbor perspectives in biology · 2012Review
- PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A mouse monoclonal antibody against the γ2 subunit of GABAA receptors.Hybridoma (2005) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The neuronal nicotinic synapse plays a central role in normal cognitive and autonomic function. Molecular mechanisms that direct the assembly of this synapse remain poorly defined, however. We show here that adenomatous polyposis coli (APC) organizes a multi-molecular complex that is essential for targeting alpha3(*)nAChRs to synapses. APC interaction with microtubule plus-end binding protein EB1 is required for alpha3(*)nAChR surface membrane insertion and stabilization. APC brings together EB1, the key cytoskeletal regulators macrophin and IQGAP1, and 14-3-3 adapter protein at nicotinic synapses. 14-3-3, in turn, links the alpha3-subunit to APC. This multi-molecular APC complex stabilizes the local microtubule and F-actin cytoskeleton and links postsynaptic components to the cytoskeleton--essential functions for controlling the molecular composition and stability of synapses. This work identifies macrophin, IQGAP1 and 14-3-3 as novel nicotinic synapse components and defines a new role for APC as an in vivo coordinator of nicotinic postsynaptic assembly in vertebrate neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.