ArticleNeuroscience2008
Tonic and stimulus-evoked nitric oxide production in the mouse olfactory bulb.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Metalloneurochemistry and the Pierian Spring: 'Shallow Draughts Intoxicate the Brain'.Israel journal of chemistry · 2016Article
- Nitric Oxide-Mediated Modulation of Central Network Dynamics during Olfactory Perception.PloS one · 2015Article
- Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling.PloS one · 2015Article
- Nitric oxide affects short-term olfactory memory in the antennal lobe of Manduca sexta.The Journal of experimental biology · 2013Article
- Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.Chemical senses · 2013Review
- Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.PloS one · 2013Article
- Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase.Experimental neurology · 2012Article
- Nitric oxide signaling in the microcirculation.Critical reviews in biomedical engineering · 2011Review
- Cell-trappable fluorescent probes for nitric oxide visualization in living cells.Organic letters · 2010Article
- Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper(II) fluorescent probe.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- What is the real physiological NO concentration in vivo?Nitric oxide : biology and chemistry · 2009Review
- Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: a quantitative analysis.Microvascular research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local interneurons of the olfactory bulb. Here we employ innovative custom-fabricated NO micro-sensors to obtain the first direct, time-resolved measurements of NO signaling in the olfactory bulb. In 400 microm thick mouse olfactory bulb slices, we detected a steady average basal level of 87 nM NO in the extracellular space of mitral or granule cell layers. This NO 'tone' was sensitive to NOS substrate manipulation (200 microM L-arginine, 2 mM N(G)-nitro-L-arginine methyl ester) and Mg(2+) modulation of N-methyl-D-aspartate (NMDA) receptor conductance. Electrical stimulation of olfactory nerve fibers evoked transient (peak at 10 s) increments in NO levels 90-100 nM above baseline. In the anesthetized mouse, NO micro-sensors inserted into the granule cell layer detected NO transients averaging 55 nM in amplitude and peaking at 3.4 s after onset of a 5 s odorant stimulation. These findings suggest dual roles for NO signaling in the olfactory bulb: tonic inhibitory control of principal neurons, and regulation of circuit dynamics during odor information processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.