ReviewBlood cells, molecules & diseases
Mast cell transcriptional networks.
Review in Blood cells, molecules & diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The Role of Mast Cells and Their Potential as a Therapeutic Target For Neuroinflammation.Journal of inflammation research · 2026Review
- Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation.Immunological reviews · 2025Review
- Mast Cell Activation in the Systemic Sclerosis Esophagus.Journal of scleroderma and related disorders · 2021Article
- Transcription Factors in the Development and Pro-Allergic Function of Mast Cells.Frontiers in allergy · 2021Review
- Basophils and Eosinophils in Nematode Infections.Frontiers in immunology · 2020Review
- The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway.JCI insight · 2018Article
- The gestational power of mast cells in the injured tissue.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Transcriptional regulation of mast cell and basophil lineage commitment.Seminars in immunopathology · 2016Review
- The STAT5-GATA2 pathway is critical in basophil and mast cell differentiation and maintenance.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Global microRNA expression is essential for murine mast cell development in vivo.Experimental hematology · 2014Article
- Mechanisms controlling mast cell and basophil lineage decisions.Current allergy and asthma reports · 2014Review
- Identification of microRNAs regulating the developmental pathways of bone marrow derived mast cells.PloS one · 2014Article
- Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates.Immunity · 2013Article
- The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.Blood · 2011Article
- Increased differentiation of dermal mast cells in mice lacking the Mpl gene.Stem cells and development · 2009Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.