ReviewBiochimica et biophysica acta2008
Lipid peroxidation and decomposition--conflicting roles in plaque vulnerability and stability.
Review in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Vitamin E differentially affects short term exercise induced changes in oxidative stress, lipids, and inflammatory markers.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2012Trial
- Strenuous Exercise and Quercetin Supplementation Differentially Alter Lipid Metabolism in C57BL/6J Mice.Journal of lipid and atherosclerosis · 2026Article
- Commemorating Dr. Sampath (Sam) Parthasarathy for his Exceptional Research in Biochemistry and Lipidology in Health and Diseaseand Legacy as a Superb Mentor and Scientist.Cell biochemistry and biophysics · 2026Article
- Jingzhi Guanxin Oral Liquids Attenuate Atherosclerotic Coronary Heart Disease via Modulating Lipid Metabolism and PPAR-Related Targets.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Red Blood Cells' Omega-6 and Omega-3 Polyunsaturated Fatty Acids Have a Distinct Influence on LDL Particle Size and its Structural Modifications.Arquivos brasileiros de cardiologia · 2023Article
- Dietary Oxidized Linoleic Acids Modulate Fatty Acids in Mice.Journal of lipid and atherosclerosis · 2022Article
- Eicosanoids: Atherosclerosis and cardiometabolic health.Journal of clinical & translational endocrinology · 2020Review
- A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia.Nutrients · 2019Review
- Dietary Strategies Implicated in the Prevention and Treatment of Metabolic Syndrome.International journal of molecular sciences · 2016Review
- 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.Oxidative medicine and cellular longevity · 2016Review
- N-acetylcysteine inhibits in vivo oxidation of native low-density lipoprotein.Scientific reports · 2015Article
- Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation.Journal of the International Society of Sports Nutrition · 2014Article
- Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity.International journal of molecular sciences · 2013Review
- The emerging role of outdoor and indoor air pollution in cardiovascular disease.North American journal of medical sciences · 2013Review
- Markers of oxidant stress that are clinically relevant in aging and age-related disease.Mechanisms of ageing and development · 2013Review
- Platelet nitric oxide signaling system in patients with coronary artery disease.Annals of vascular diseases · 2011Article
- Apolipoprotein A-I mimetic peptides prevent atherosclerosis development and reduce plaque inflammation in a murine model of diabetes.Diabetes · 2010Article
- L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice.Drug metabolism letters · 2010Article
- Oxidized LDL: diversity, patterns of recognition, and pathophysiology.Antioxidants & redox signaling · 2010Review
- Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.Antioxidants & redox signaling · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The low density lipoprotein (LDL) oxidation hypothesis has generated considerable interest in oxidative stress and how it might affect atherosclerosis. However, the failure of antioxidants, particularly vitamin E, to affect the progression of the disease in humans has convinced even staunch supporters of the hypothesis to take a step backwards and reconsider alternatives. Preponderant evidence for the hypothesis came from animal antioxidant intervention studies. In this review we point out basic differences between animal and human atherosclerosis development and suggest that human disease starts where animal studies end. While initial oxidative steps in the generation of early fatty streak lesions might be common, the differences might be in the steps involved in the decomposition of peroxidized lipids into aldehydes and their further oxidation into carboxylic acids. We suggest that these steps may not be amenable to attenuation by antioxidants and antioxidants might actually counter the stabilization of plaque by preventing the formation of carboxylic acids which are anti-inflammatory in nature. The formation of such dicarboxylic acids may also be conducive to plaque stabilization by trapping calcium. We suggest that agents that would prevent the decomposition of lipid peroxides and promote the formation and removal of lipid hydroxides, such as paraoxonase (PON 1) or apo A1/high density lipoprotein (HDL) might be more conducive to plaque regression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.