ArticleInsect biochemistry and molecular biology2008
Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster.
Article in Insect biochemistry and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Distribution and voltage dependence of ion channels shape single-neuron computations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Impact of Aedes aegypti V1016I and F1534C knockdown resistance genotypes on operational interventions.Scientific reports · 2025Article
- Differences in seasonal dynamics and pyrethroid resistance development among Anopheles Hyrcanus group species.Parasites & vectors · 2024Article
- A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors inScience advances · 2024Article
- Transient and Steady-State Properties ofFrontiers in cellular neuroscience · 2022Article
- Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.Insect biochemistry and molecular biology · 2020Article
- Paralytic, theGenes & development · 2019Article
- Milk-whey diet substantially suppresses seizure-like phenotypes ofJournal of neurogenetics · 2019Article
- Illuminating spatial A-to-I RNA editing signatures within theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Molecular basis of selective resistance of the bumblebee BiNaProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons.Neuron · 2017Article
- Model systems for studying cellular mechanisms of SCN1A-related epilepsy.Journal of neurophysiology · 2016Review
- Article
- Drosophila sodium channel mutations: Contributions to seizure-susceptibility.Experimental neurology · 2015Review
- Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.Neurotoxicology · 2015Article
- Regulation of membrane excitability: a convergence on voltage-gated sodium conductance.Molecular neurobiology · 2015Review
- Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila.Frontiers in computational neuroscience · 2015Article
- Molecular biology of insect sodium channels and pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.Neuroscience · 2014Article
- Voltage-Gated Sodium Channels as Insecticide Targets.Advances in insect physiology · 2014Article
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5 authors.
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Abstract
Extensive alternative splicing and RNA editing have been documented for the transcript of DmNa(V) (formerly para), the sole sodium channel gene in Drosophila melanogaster. However, the functional consequences of these post-transcriptional modifications are not well understood. In this study we isolated 64 full-length DmNa(V) cDNA clones from D. melanogaster adults. Based on the usage of 11 alternative exons, 64 clones could be grouped into 29 splice types. When expressed in Xenopus oocytes, 33 DmNa(V) variants generated sodium currents large enough for functional characterization. Among these variants, DmNa(V)5-1 and DmNa(V)7-1 channels activated at the most hyperpolarizing potentials, whereas DmNa(V)1-6 and DmNa(V)19 channels activated at the most depolarizing membrane potentials. We identified an A-to-I editing event in DmNa(V)5-1 that is responsible for its uniquely low-voltage-dependent activation. The wide range of voltage dependence of gating properties exhibited by DmNa(V) variants represents a rich resource for future studies to determine the role of DmNa(V) in regulating sodium channel gating, pharmacology, and neuronal excitability in insects.
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