ArticleThe international journal of neuropsychopharmacology2009
A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats.
Article in The international journal of neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats.Psychopharmacology · 2026Article
- Factors that influence the conditioned reinforcing effects of a cocaine-associated stimulus.The Journal of pharmacology and experimental therapeutics · 2025Article
- Less is more: calorie restriction as a therapeutic for mental health disorders.Frontiers in psychiatry · 2025Review
- Chronic water restriction reduces sensitivity to brain stimulation reward in male and female rats.Physiology & behavior · 2023Article
- Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges.Neuroscience and biobehavioral reviews · 2020Review
- Relapse to opioid seeking in rat models: behavior, pharmacology and circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Role of cues and contexts on drug-seeking behaviour.British journal of pharmacology · 2014Review
- Examination of the role of dopamine D₂ and adrenergic α₂ receptors in resurgence of food seeking.Behavioural brain research · 2014Article
- Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction.Psychopharmacology · 2014Review
- A procedure to study the effect of prolonged food restriction on heroin seeking in abstinent rats.Journal of visualized experiments : JoVE · 2013Article
- Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats.Journal of psychopharmacology (Oxford, England) · 2013Article
- The effects of chronic food restriction on cue-induced heroin seeking in abstinent male rats.Psychopharmacology · 2013Article
- Reinstatement of cocaine seeking in rats by the pharmacological stressors, corticotropin-releasing factor and yohimbine: role for D1/5 dopamine receptors.Psychopharmacology · 2012Article
- A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat.Psychopharmacology · 2011Article
- Effects of systemic or nucleus accumbens-directed dopamine D1 receptor antagonism on sucrose seeking in rats.Psychopharmacology · 2011Article
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4 authors.
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Abstract
Dopamine has a critical role in drug reinforcement and the reinstatement of drug seeking due to priming or exposure to drug-associated cues. In contrast, the role of dopamine in stress-induced reinstatement is not clear. We have previously demonstrated that acute food deprivation, a clinically relevant stressor, reinstates heroin seeking in rats via a leptin-dependent mechanism. Recent reports have suggested a modulating role for leptin on dopamine transmission and drug-related behaviours. Thus, here we investigated the role of dopamine in acute food deprivation-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin (0.05 mg/kg per infusion) for 10 d. Following training, heroin seeking was extinguished and rats were tested for 48-h food deprivation-induced reinstatement while pretreated with the dopamine D1-, D2-, or D3-like receptor antagonists: SCH 23390 (0.0, 5.0 or 10.0 microg/kg), raclopride (0.0, 50.0 or 100.0 microg/kg) or NGB 2904 (0.0, 0.1 or 5.0 mg/kg), respectively. The dopamine D1-like receptor antagonist, SCH 23390, but neither of the other antagonists, showed a dose-dependent attenuation of food deprivation-induced reinstatement. Our results suggest that acute food deprivation-induced reinstatement may be mediated, at least in part, by activation of the dopamine D1-like receptor.
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