ArticleJournal of biomedical materials research. Part A2009
Studies of the cellular uptake of hydrogel nanospheres and microspheres by phagocytes, vascular endothelial cells, and smooth muscle cells.
Article in Journal of biomedical materials research. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A Simple Vortex-Based Method for the Generation of High-Throughput Spherical Micro- and Nanohydrogels.International journal of molecular sciences · 2025Article
- Nanoparticles as Drug Delivery Systems for the Targeted Treatment of Atherosclerosis.Molecules (Basel, Switzerland) · 2024Review
- Size-dependent bioactivity of electrosprayed core-shell chitosan-alginate particles for protein delivery.Scientific reports · 2022Article
- Designing of CoPharmaceutics · 2021Article
- Article
- Labeling of endothelial cells with magnetic microbeads by angiophagy.Biotechnology letters · 2018Article
- Cathepsin K-targeted sub-micron particles for regenerative repair of vascular elastic matrix.Acta biomaterialia · 2017Article
- Nanoparticulate delivery of agents for induced elastogenesis in three-dimensional collagenous matrices.Journal of tissue engineering and regenerative medicine · 2016Article
- Nanotechnology in diagnosis and treatment of coronary artery disease.Nanomedicine (London, England) · 2016Review
- Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Multi-ligand poly(L-lactic-co-glycolic acid) nanoparticles inhibit activation of endothelial cells.Journal of cardiovascular translational research · 2013Article
- Multifunctional nanoparticles for doxycycline delivery towards localized elastic matrix stabilization and regenerative repair.Acta biomaterialia · 2013Article
- Advances in biomimetic regeneration of elastic matrix structures.Drug delivery and translational research · 2012Article
- Biomaterial implants mediate autologous stem cell recruitment in mice.Acta biomaterialia · 2011Article
- Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective.Vascular cell · 2011Article
- Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Intensive research efforts have been placed on the development of nanospheres for targeted drug delivery for treating a variety of diseases, including coronary restenosis, cancer, and inflammatory reactions. Although most of these drug-bearing spheres are delivered via intravenous administration, little is known about the effect of sphere physical characteristics on the responses of vascular and blood cells. To find the answer, this work was aimed to investigate the cellular uptake of nanosized (100 nm) and microsized hydrogel spheres (1 microm) made of poly(N-isopropylacrylamide) by vascular cells and phagocytes under various flow conditions in vitro. We found that the cellular uptake of nanospheres depended on incubation times and sphere concentrations as well as on the introduced shear stress levels of the medium. Measurements of the intracellular-released fluorescence and confocal fluorescence microscopy revealed that nanospheres were internalized by endothelial cells and smooth muscle cells more than microspheres, whereas microspheres were rapidly taken up by phagocytes, especially at high concentration. Our results strongly suggest that hydrogel nanospheres are more effective as an intravascular delivery system compared to microspheres in the terms of vascular cellular uptake and biocompatibility.
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Registered trials
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