ArticlePurinergic signalling2005
Extracellular zinc and ATP-gated P2X receptor calcium entry channels: New zinc receptors as physiological sensors and therapeutic targets.
Article in Purinergic signalling, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- In Vitro Evaluation of Anti-Inflammatory and Antioxidant Properties of a Novel Calcium Alginate-Zinc Hemostatic Biomaterial.Journal of functional biomaterials · 2026Article
- A new hemostatic agent composed of ZnBioactive materials · 2022Article
- Neuronal signalling of zinc: from detection and modulation to function.Open biology · 2022Review
- Article
- MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx.Autophagy · 2021Article
- The Function and Regulation of Zinc in the Brain.Neuroscience · 2021Review
- Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior.Brain sciences · 2019Review
- Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Arsenic alters ATP-dependent Ca²+ signaling in human airway epithelial cell wound response.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion.Purinergic signalling · 2008Article
- Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals.Purinergic signalling · 2008Article
- Purinergic signaling microenvironments: An introduction.Purinergic signalling · 2008Article
- Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts.Purinergic signalling · 2008Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In this review, we focus on two attributes of P2X receptor channel function, one essential and one novel. First, we propose that P2X receptors are extracellular sensors as well as receptors and ion channels. In particular, the large extracellular domain (that comprises 70% of the molecular mass of the receptor channel protein) lends itself to be a cellular sensor. Moreover, its exquisite sensitivity to extracellular pH, ionic strength, and multiple ligands evokes the function of a sensor. Second, we propose that P2X receptors are extracellular zinc receptors as well as receptors for nucleotides. We provide novel data in multiple publications and illustrative data in this invited review to suggest that zinc triggers ATP-independent activation of P2X receptor channel function. In this light, P2X receptors are the cellular site of integration between autocrine and paracrine zinc signaling and autocrine and paracrine purinergic signaling. P2X receptors may sense changes in these ligands as well as in extracellular pH and ionic strength and transduce these sensations via calcium and/or sodium entry and changes in membrane potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.