ArticlePurinergic signalling2005
Dynamic purine signaling and metabolism during neutrophil-endothelial interactions.
Article in Purinergic signalling, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.The Journal of clinical investigation · 2022Article
- Alternative adenosine Receptor activation: The netrin-Adora2b link.Frontiers in pharmacology · 2022Review
- Metabolic regulation of intestinal epithelial barrier during inflammation.Tissue barriers · 2015Article
- Adenosine A2B receptor modulates intestinal barrier function under hypoxic and ischemia/reperfusion conditions.International journal of clinical and experimental pathology · 2014Article
- Targeting Hypoxia to Augment Mucosal Barrier Function.Journal of epithelial biology & pharmacology · 2012Article
- Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium.American journal of respiratory cell and molecular biology · 2011Article
- The therapeutic potential of adenosine triphosphate as an immune modulator in the treatment of HIV/AIDS: a combination approach with HAART.Current HIV research · 2011Article
- P2Y receptors as regulators of lung endothelial barrier integrity.Journal of cardiovascular disease research · 2011Article
- Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury.Transplantation · 2010Article
- Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability.Trends in immunology · 2009Review
- Adenosine: an old drug newly discovered.Anesthesiology · 2009Review
- ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia.PloS one · 2008Article
- Physiological roles for ecto-5'-nucleotidase (CD73).Purinergic signalling · 2006Article
- Invited Lectures : Overviews Purinergic signalling: past, present and future.Purinergic signalling · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During episodes of hypoxia and inflammation, polymorphonuclear leukocytes (PMN) move into underlying tissues by initially passing between endothelial cells that line the inner surface of blood vessels (transendothelial migration, TEM). TEM creates the potential for disturbances in vascular barrier and concomitant loss of extravascular fluid and resultant edema. Recent studies have demonstrated a crucial role for nucleotide metabolism and nucleoside signaling during inflammation. These studies have implicated multiple adenine nucleotides as endogenous tissue protective mechanisms invivo. Here, we review the functional components of vascular barrier, identify strategies for increasing nucleotide generation and nucleoside signaling, and discuss potential therapeutic targets to regulate the vascular barrier during inflammation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.