ArticlePurinergic signalling2005
Purinergic mechanism in the immune system: A signal of danger for dendritic cells.
Article in Purinergic signalling, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 93 citations in OpenAlex.
- Nanoadjuvant-integrated organic biomaterials for immune engineering: Mechanisms, design strategies, and translational applications.Materials today. Bio · 2026Review
- Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Partners in health and disease: pineal gland and purinergic signalling.Purinergic signalling · 2025Review
- Understanding the genetic complexity of Leishmania infantum in the Americas: a focus on 3'NT/NU gene deletion.Memorias do Instituto Oswaldo Cruz · 2025Review
- Purinergic Receptors in Dendritic Cells.Journal of inflammation research · 2025Review
- Adenosine pathway regulates inflammation duringFrontiers in immunology · 2023Article
- Computational modelling and simulation for immunotoxicity prediction induced by skin sensitisers.Computational and structural biotechnology journal · 2022Article
- Inositol 1,4,5-trisphosphate 3-kinase B promotes CaScience signaling · 2021Article
- Review
- Immunosuppression in GliomasFrontiers in oncology · 2020Review
- Dendritic Cell-Mediated Th2 Immunity and Immune Disorders.International journal of molecular sciences · 2019Review
- Ecto-enzymes activities in splenic lymphocytes of mice experimentally infected by Trypanosoma cruzi and treated with specific avian immunoglobulins: an attempt to improve the immune response.Molecular and cellular biochemistry · 2018Article
- Infection of Human Macrophages byFrontiers in immunology · 2017Article
- Article
- Article
- Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells.Seminars in immunopathology · 2016Review
- Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response.Biomedical journal · 2016Review
- Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury.Cell stress & chaperones · 2016Article
- Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells.Journal of leukocyte biology · 2016Article
- Rhein antagonizes P2X7 receptor in rat peritoneal macrophages.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing appreciation that injured or stressed cells release molecules endowed with the ability to modulate dendritic cell maturation. The role of these molecules is thought to be that of alerting the body of an impending danger, and initiate and shape the subsequent immune response. Nucleotides are perfectly suited for this task as they are easily released upon damage of the cell membrane, rapidly diffuse in the extracellular environment and ligate specific plasma membrane receptors expressed by dendritic cells and other mononuclear phagocytes. A better knowledge of the modulation of dendritic cell responses by extracellular nucleotides may provide novel routes to enhance the immune response and increase the efficacy of vaccination.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.