ArticlePurinergic signalling2006
Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks.
Article in Purinergic signalling, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Recombinant-Chemosynthetic Biosensors for Probing Cell Surface Signaling of Red Blood Cells and Other Cells.Chemical & biomedical imaging · 2025Article
- P2Y1 receptor in Alzheimer's disease.Neural regeneration research · 2025Article
- Pyrimidinergic P2Y1-Like Nucleotide Receptors Are Functional in Rat Conjunctival Goblet Cells.Investigative ophthalmology & visual science · 2025Article
- Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model.Molecular neurobiology · 2024Article
- Independent association of Lp(a) with platelet reactivity in subjects without statins or antiplatelet agents.Scientific reports · 2022Article
- Inorganic Polyphosphate-Regulator of Cellular Metabolism in Homeostasis and Disease.Biomedicines · 2022Review
- Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches.International journal of molecular sciences · 2022Review
- Exogenous NADBiomolecules · 2020Article
- Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology.International journal of biological sciences · 2020Review
- Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of CaThe Journal of biological chemistry · 2019Article
- POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages.Purinergic signalling · 2017Article
- Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells.Seminars in immunopathology · 2016Review
- Expression of purinergic receptor P2Y4 in Schwann cell following nerve regeneration.International journal of clinical and experimental medicine · 2015Article
- Targeted activation of conventional and novel protein kinases C through differential translocation patterns.Molecular and cellular biology · 2014Article
- Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.Molecular pain · 2014Article
- Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain.Molecular pain · 2014Article
- Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.PloS one · 2014Article
- N-cadherin expression is regulated by UTP in schwannoma cells.Purinergic signalling · 2013Article
- Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function.Purinergic signalling · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of nucleotides in intracellular energy provision and nucleic acid synthesis has been known for a long time. In the past decade, evidence has been presented that, in addition to these functions, nucleotides are also autocrine and paracrine messenger molecules that initiate and regulate a large number of biological processes. The actions of extracellular nucleotides are mediated by ionotropic P2X and metabotropic P2Y receptors, while hydrolysis by ecto-enzymes modulates the initial signal. An increasing number of studies have been performed to obtain information on the signal transduction pathways activated by nucleotide receptors. The development of specific and stable purinergic receptor agonists and antagonists with therapeutical potential largely contributed to the identification of receptors responsible for nucleotide-activated pathways. This article reviews the signal transduction pathways activated by P2Y receptors, the involved second messenger systems, GTPases and protein kinases, as well as recent findings concerning P2Y receptor signalling in C6 glioma cells. Besides vertical signal transduction, lateral cross-talks with pathways activated by other G protein-coupled receptors and growth factor receptors are discussed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.