ArticlePurinergic signalling2007
Shaping immune responses through the activation of dendritic cells' P2 receptors.
Article in Purinergic signalling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review).Oncology letters · 2024Review
- Physiologic roles of P2 receptors in leukocytes.Journal of leukocyte biology · 2022Review
- CD47 as a promising therapeutic target in oncology.Frontiers in immunology · 2022Review
- CD47: role in the immune system and application to cancer therapy.Cellular oncology (Dordrecht, Netherlands) · 2020Review
- Targeting Purinergic Signaling in the Dynamics of Disease Progression in Sepsis.Frontiers in pharmacology · 2020Article
- P2X4 receptors, immunity, and sepsis.Current opinion in pharmacology · 2019Review
- ATP and Its Metabolite Adenosine as Regulators of Dendritic Cell Activity.Frontiers in immunology · 2018Review
- Purinergic Signaling and the Immune Response in Sepsis: A Review.Clinical therapeutics · 2016Review
- Purinergic signalling and immune cells.Purinergic signalling · 2014Review
- Regulation of innate immunity by extracellular nucleotides.American journal of blood research · 2013Article
- Isolated closed minor-muscle injury of the lower leg did not cause an obvious systemic immune response.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) activate and shape the adaptive immune response by capturing antigens, migrating to peripheral lymphoid organs where naïve T cells reside, expressing high levels of MHC and costimulatory molecules and secreting cytokines and chemokines. DCs are endowed with a high degree of functional plasticity and their functions are tightly regulated. Besides initiating adaptive immune responses, DCs play a key role in maintaining peripheral tolerance toward self-antigens. On the basis of the information gathered from the tissue where they reside, DCs adjust their functional activity to ensure that protective immunity is favoured while unwanted or exaggerated immune responses are prevented. A wide variety of signals from neighbouring cells affecting DC functional activity have been described. Here we will discuss the complex role of extracellular nucleotides in the regulation of DC function and the role of P2 receptors as possible tools to manipulate immune responses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.