ArticlePurinergic signalling2007
Chemotactic activity of extracellular nucleotideson human immune cells.
Article in Purinergic signalling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration.Cell proliferation · 2025Review
- Possible Roles for Purinergic Receptor P2RX4 in Breast and Prostate Cancers.International journal of molecular sciences · 2025Review
- Baseline Gut Microbiota Was Associated with Long-Term Immune Response at One Year Following Three Doses of BNT162b2.Vaccines · 2024Article
- Cell-type-specific role of P2Y2 receptor in HDM-driven model of allergic airway inflammation.Frontiers in immunology · 2023Article
- Tumour immune escape via P2X7 receptor signalling.Frontiers in immunology · 2023Review
- Article
- The Phagocytic Code Regulating Phagocytosis of Mammalian Cells.Frontiers in immunology · 2021Review
- P2X7 Receptor at the Crossroads of T Cell Fate.International journal of molecular sciences · 2020Review
- Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSOJournal of neuroinflammation · 2020Article
- Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.Nature communications · 2020Article
- DAMP-sensing receptors in sterile inflammation and inflammatory diseases.Nature reviews. Immunology · 2020Review
- Important roles of P2Y receptors in the inflammation and cancer of digestive system.Oncotarget · 2016Review
- P2X ion channel receptors and inflammation.Purinergic signalling · 2016Review
- Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation.PloS one · 2016Article
- Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response.PloS one · 2015Article
- The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis.Journal of innate immunity · 2015Article
- Purinergic signalling and immune cells.Purinergic signalling · 2014Review
- Nucleotide signalling during inflammation.Nature · 2014Review
- Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses.Purinergic signalling · 2013Review
- Many faces of DAMPs in cancer therapy.Cell death & disease · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purinergic P2 receptors are a class of plasma membrane receptors that are express in many tissues and are ligated by extracellular nucleotides [such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP)], which are released as a consequence of cell damage, cell stress, bacterial infection or other noxious stimuli. According to the molecular structure, P2 receptors are divided into two subfamilies: P2X and P2Y receptors. The P2X receptors are ligand-gated channels, whereas P2Y receptors are G-protein-coupled seven-membrane-spanning receptors. Several studies indicate that nucleotides play an important role in immune response modulation through their action on multiple cell types, including monocytes, mast cells, dendritic cells, neutrophils, and eosinophils. Recent work by our group and others identified extracellular nucleotides as chemotaxins for various human immune cells, including eosinophils, neutrophils and dendritic cells. In this review, we summarise recent findings in this field and put forward a hypothesis on the role of P2 receptors in the early recruitment of human immune cells to the site of inflammation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.