ArticleBreast cancer research and treatment2009
Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence.
Article in Breast cancer research and treatment, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Promoter hypermethylation profiling of distant breast cancer metastases.Breast cancer research and treatment · 2015Article
- Quantitative detection of methylated NDRG4 gene as a candidate biomarker for diagnosis of colorectal cancer.Oncology letters · 2015Article
- Breast cancer nodal metastasis correlates with tumour and lymph node methylation profiles of Caveolin-1 and CXCR4.Clinical & experimental metastasis · 2014Article
- Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.Leukemia & lymphoma · 2010Article
- Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers.BMC cancer · 2010Article
- Cancer DNA methylation: molecular mechanisms and clinical implications.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
purposePromoter methylation of tumor suppressor genes in histologically negative sentinel lymph nodes (HNSN) of early stage breast cancer patients has not been extensively studied. This study evaluates the methylation frequency and pattern in HNSN to determine if detection of hypermethylation of one or more genes is associated with an increased recurrence risk in node negative breast cancer. EXPERIMENTAL
designIn 1998, a prospective study of patients with early stage breast cancer and HNSN was initiated in order to correlate sentinel node analysis with clinical outcome. Nodal tissue was selected from 120 HNSN patients for methylation analysis in at least one and up to six sentinel nodes using a panel of nine genes. Corresponding primary breast tumors from 79 patients were also evaluated for hypermethylation. Methylation analysis was performed using nested Methylation Sensitive PCR (n-MSP). Logistical regression was used to evaluate the relationship between clinical recurrence and methylation status.
resultsOver a median follow-up of 79 months, 13 of the 120 patients had clinical recurrence. Hypermethylation of genes was frequently observed in HNSN, but there was no correlation of methylation pattern and clinical recurrence. However, increased frequency of gene methylation of the primary tumor correlated with clinical recurrence.
conclusionsAlthough hypermethylation of multiple genes occurs frequently in HNSN of breast cancer patients, it is not associated with breast cancer recurrence in the first 7 years of clinical follow-up.
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