ArticleJournal of natural medicines2008
Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models.
Article in Journal of natural medicines, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Kaemphenolide: a cyclobutane-bearing phenylpropanoid from Kaempferia galanga L. with nitric oxide inhibitory activity.Natural products and bioprospecting · 2025Article
- Antioxidant Effect of Ethyl Acetate Fraction fromAntioxidants (Basel, Switzerland) · 2025Article
- Article
- Exploring Volatile Organic Compounds in Rhizomes and Leaves ofMetabolites · 2023Article
- Chemical composition of theFrontiers in nutrition · 2023Article
- Novel ethyl p-methoxy cinnamate richPeerJ · 2023Article
- Extract, fractions, and ethyl-Journal of traditional and complementary medicine · 2021Article
- Analysis of Lipophilic Antioxidants in the Leaves ofAntioxidants (Basel, Switzerland) · 2021Article
- Establishment of a Rapid Micropropagation System forPlants (Basel, Switzerland) · 2021Article
- Review
- Immunomodulatory and Antioxidant Activities of Select Indonesian Vegetables, Herbs, and Spices on Human Lymphocytes.International journal of food science · 2021Article
- Cytotoxicity, Cell Cycle Arrest, and Apoptosis Induction Activity of Ethyl-p-methoxycinnamate in Cholangiocarcinoma Cell.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice.BMC complementary and alternative medicine · 2015Article
- Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions.Clinics (Sao Paulo, Brazil) · 2014Article
- Antiartherosclerotic effects of plant flavonoids.BioMed research international · 2014Review
- Bioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galanga L. extracts.Molecules (Basel, Switzerland) · 2012Article
- Molecular cloning, characterization, and expression analysis of resistance gene candidates in Kaempferia galanga L.Molecular biotechnology · 2012Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH(2)O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc.
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