ArticlePLoS computational biology2008
Estimating cell depth from somatic mutations.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging.PLoS biology · 2026Article
- Quantifying cell divisions along evolutionary lineages in cancer.Nature genetics · 2025Article
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- Connecting past and present: single-cell lineage tracing.Protein & cell · 2022Review
- Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development.Nature methods · 2021Article
- Applications of Single-Cell DNA Sequencing.Annual review of genomics and human genetics · 2021Review
- Alignment of Cell Lineage Trees Elucidates Genetic Programs for the Development and Evolution of Cell Types.iScience · 2020Article
- Sample path properties of the average generation of a Bellman-Harris process.Journal of mathematical biology · 2019Article
- Inferring average generation via division-linked labeling.Journal of mathematical biology · 2016Article
- Theory and Practice of Lineage Tracing.Stem cells (Dayton, Ohio) · 2015Review
- Aging, clonal hematopoiesis and preleukemia: not just bad luck?International journal of hematology · 2015Review
- Elevated germline mutation rate in teenage fathers.Proceedings. Biological sciences · 2015Article
- Hypermutable DNA chronicles the evolution of human colon cancer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Single-cell sequencing-based technologies will revolutionize whole-organism science.Nature reviews. Genetics · 2013Review
- Article
- Comparing algorithms that reconstruct cell lineage trees utilizing information on microsatellite mutations.PLoS computational biology · 2013Article
- Oocyte family trees: old branches or new stems?PLoS genetics · 2012Review
- Cell lineage analysis of the mammalian female germline.PLoS genetics · 2012Article
- Decoding cell lineage from acquired mutations using arbitrary deep sequencing.Nature methods · 2011Article
- Colon stem cell and crypt dynamics exposed by cell lineage reconstruction.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The depth of a cell of a multicellular organism is the number of cell divisions it underwent since the zygote, and knowing this basic cell property would help address fundamental problems in several areas of biology. At present, the depths of the vast majority of human and mouse cell types are unknown. Here, we show a method for estimating the depth of a cell by analyzing somatic mutations in its microsatellites, and provide to our knowledge for the first time reliable depth estimates for several cells types in mice. According to our estimates, the average depth of oocytes is 29, consistent with previous estimates. The average depth of B cells ranges from 34 to 79, linearly related to the mouse age, suggesting a rate of one cell division per day. In contrast, various types of adult stem cells underwent on average fewer cell divisions, supporting the notion that adult stem cells are relatively quiescent. Our method for depth estimation opens a window for revealing tissue turnover rates in animals, including humans, which has important implications for our knowledge of the body under physiological and pathological conditions.
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