ArticleEndocrinology2008
Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Response of gonadotropin-releasing hormone neurons from female mice to dynamic-clamp-simulated GABAergic conductances across development and after prenatal androgenization.Journal of neuroendocrinology · 2026Article
- Gonadal Feedback Alters the Relationship between Action Potentials and Hormone Release in Gonadotropin-Releasing Hormone Neurons in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cellular Localization of Orexin 1 Receptor in Human Hypothalamus and Morphological Analysis of Neurons Expressing the Receptor.Biomolecules · 2023Article
- The electrophysiologic properties of gonadotropin-releasing hormone neurons.Journal of neuroendocrinology · 2022Review
- Efficient dendritic learning as an alternative to synaptic plasticity hypothesis.Scientific reports · 2022Article
- Article
- Diversity of Axonal and Dendritic Contributions to Neuronal Output.Frontiers in cellular neuroscience · 2019Article
- Maternal Dexamethasone Exposure Alters Synaptic Inputs to Gonadotropin-Releasing Hormone Neurons in the Early Postnatal Rat.Frontiers in endocrinology · 2016Article
- Expression of Vesicular Glutamate Transporter 2 (vGluT2) on Large Dense-Core Vesicles within GnRH Neuroterminals of Aging Female Rats.PloS one · 2015Article
- Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons.Molecular brain · 2014Article
- Afferent neuronal control of type-I gonadotropin releasing hormone neurons in the human.Frontiers in endocrinology · 2013Review
- GnRH neurons elaborate a long-range projection with shared axonal and dendritic functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Simulated GABA synaptic input and L-type calcium channels form functional microdomains in hypothalamic gonadotropin-releasing hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A simple integrative electrophysiological model of bursting GnRH neurons.Journal of computational neuroscience · 2012Article
- Initiation and propagation of action potentials in gonadotropin-releasing hormone neuron dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotrophin-releasing hormone neurones: towards an emerging consensus.Journal of neuroendocrinology · 2011Review
- Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons.Molecular brain · 2011Article
- Spatially selective, testosterone-independent remodeling of dendrites in gonadotropin-releasing hormone (GnRH) neurons prepubertally in male rats.Endocrinology · 2011Article
- Identified GnRH neuron electrophysiology: a decade of study.Brain research · 2010Review
- The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.Endocrine reviews · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
It is dogma that action potentials are initiated at the soma/axon hillock of neurons. However, dendrites often exhibit conductances necessary for spike generation and represent functionally independent processing compartments within neurons. GnRH neurons provide an interesting neuronal phenotype with simple, relatively unbranched, unipolar or bipolar dendrites of extensive lengths (>1000 microm) covered in spines. These neurons control fertility and must integrate a variety of internal homeostatic and external environmental cues. We used imaging, electrophysiological, and modeling studies to understand how they integrate and process information along dendrites. Simultaneous recordings from distal dendrites and somata of individual GnRH neurons indicate distal dendrites are the primary site of spike initiation in these cells. Compartmental modeling indicates that sites of spike initiation depend upon location of excitatory input and dendrite geometry. Together, these studies demonstrate a novel pattern of spike generation in mammalian neurons and indicate that afferent inputs within distal dendritic microdomains directly initiate action potentials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.