ArticleThe Journal of physiology2008
Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Effects of vasodilator and esmolol-induced hemodynamic stability on early post-operative cognitive dysfunction in elderly patients: a randomized trial.African health sciences · 2016Trial
- Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension.Neurocritical care · 2010Trial
- Age alters integrated cerebrovascular and cardiovascular dynamic responses to exercise: insights from a systems modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments.Neuroscience and biobehavioral reviews · 2023Review
- Trans-cerebral HCOJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives.International journal of molecular sciences · 2021Review
- Cerebrovascular responses to graded exercise in young healthy males and females.Physiological reports · 2020Article
- Measurement and Changes in Cerebral Oxygenation and Blood Flow at Rest and During Exercise in Normotensive and Hypertensive Individuals.Current hypertension reports · 2020Review
- Dynamic cerebral autoregulation across the cardiac cycle during 8 hr of recovery from acute exercise.Physiological reports · 2020Article
- TCD Cerebral Hemodynamic Changes during Moderate-Intensity Exercise in Older Adults.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The GlyFrontiers in physiology · 2017Article
- Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia.The Journal of physiology · 2016Article
- Brain Glycogen Decreases During Intense Exercise Without Hypoglycemia: The Possible Involvement of Serotonin.Neurochemical research · 2015Article
- Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings.Metabolic brain disease · 2015Review
- Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.Journal of neurotrauma · 2013Article
- Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals.The Journal of physiology · 2013Article
- Brain glycogen decreases during prolonged exercise.The Journal of physiology · 2011Article
- Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress.Frontiers in pharmacology · 2011Article
- Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans.The Journal of physiology · 2010Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intense exercise decreases the cerebral metabolic ratio of oxygen to carbohydrates [O(2)/(glucose + (1/2)lactate)], but whether this ratio is influenced by adrenergic stimulation is not known. In eight males, incremental cycle ergometry increased arterial lactate to 15.3 +/- 4.2 mm (mean +/- s.d.) and the arterial-jugular venous (a-v) difference from -0.02 +/- 0.03 mm at rest to 1.0 +/- 0.5 mm (P < 0.05). The a-v difference for glucose increased from 0.7 +/- 0.3 to 0.9 +/- 0.1 mm (P < 0.05) at exhaustion and the cerebral metabolic ratio decreased from 5.5 +/- 1.4 to 3.0 +/- 0.3 (P < 0.01). Administration of a non-selective beta-adrenergic (beta(1) + beta(2)) receptor antagonist (propranolol) reduced heart rate (69 +/- 8 to 58 +/- 6 beats min(-1)) and exercise capacity (239 +/- 42 to 209 +/- 31 W; P < 0.05) with arterial lactate reaching 9.4 +/- 3.6 mm. During exercise with propranolol, the increase in a-v lactate difference (to 0.5 +/- 0.5 mm; P < 0.05) was attenuated and the a-v glucose difference and the cerebral metabolic ratio remained at levels similar to those at rest. Together with the previous finding that the cerebral metabolic ratio is unaffected during exercise with administration of the beta(1)-receptor antagonist metropolol, the present results suggest that the cerebral metabolic ratio decreases in response to a beta(2)-receptor mechanism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.