ArticleCurrent biology : CB2008
Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes.
Article in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 194 citations in OpenAlex.
- ExploringJournal of medical microbiology · 2026Review
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- Factors contributing to organelle genomes size variation and the intracellular DNA transfer in Polygonaceae.BMC genomics · 2024Article
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- Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications.BMC plant biology · 2024Article
- Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria.PLoS genetics · 2023Article
- The energy metabolism of Balantidium polyvacuolum inhabiting the hindgut of Xenocypris davidi.BMC genomics · 2023Article
- Comparative Transcriptomics ofInternational journal of molecular sciences · 2023Article
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- Localization and functional characterization of the alternative oxidase in Naegleria.The Journal of eukaryotic microbiology · 2022Article
- High quality genome assembly of the amitochondriate eukaryoteMicrobial genomics · 2021Article
- Establishing a Metabolite Extraction Method to Study the Metabolome ofMolecules (Basel, Switzerland) · 2021Article
- Gregarine single-cell transcriptomics reveals differential mitochondrial remodeling and adaptation in apicomplexans.BMC biology · 2021Article
- The Complete Mitogenome ofFrontiers in plant science · 2021Article
- Gut microbiota profiles in diarrheic patients with co-occurrence of Clostridioides difficile and Blastocystis.PloS one · 2021Article
- Succinate dehydrogenase gene as a marker for studyingHeliyon · 2020Article
- Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.Microbiology and molecular biology reviews : MMBR · 2020Review
- Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies.Microbiome · 2019Article
- Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes.Scientific reports · 2019Article
- Mitochondrial Glycolysis in a Major Lineage of Eukaryotes.Genome biology and evolution · 2018Article
3 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 2 countries.
Funding
Abstract
Blastocystis is a unicellular stramenopile of controversial pathogenicity in humans. Although it is a strict anaerobe, Blastocystis has mitochondrion-like organelles with cristae, a transmembrane potential and DNA. An apparent lack of several typical mitochondrial pathways has led some to suggest that these organelles might be hydrogenosomes, anaerobic organelles related to mitochondria. We generated 12,767 expressed sequence tags (ESTs) from Blastocystis and identified 115 clusters that encode putative mitochondrial and hydrogenosomal proteins. Among these is the canonical hydrogenosomal protein iron-only [FeFe] hydrogenase that we show localizes to the organelles. The organelles also have mitochondrial characteristics, including pathways for amino acid metabolism, iron-sulfur cluster biogenesis, and an incomplete tricarboxylic acid cycle as well as a mitochondrial genome. Although complexes I and II of the electron transport chain (ETC) are present, we found no evidence for complexes III and IV or F1Fo ATPases. The Blastocystis organelles have metabolic properties of aerobic and anaerobic mitochondria and of hydrogenosomes. They are convergently similar to organelles recently described in the unrelated ciliate Nyctotherus ovalis. These findings blur the boundaries between mitochondria, hydrogenosomes, and mitosomes, as currently defined, underscoring the disparate selective forces that shape these organelles in eukaryotes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.