Evidence map›Paper›PMID 18403028›Full record

ArticleJournal of virological methods2008

SV40 reporter viruses.

Rebecca B Katzman, Mark Seeger, Kathleen Rundell

Open access · greenAbstract read
In one paragraph

Article in Journal of virological methods, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebecca B KatzmanDepartment of Microbiology-Immunology and The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA. rebeccab@northwestern.edu
Mark Seeger
Kathleen Rundell
Northwestern University · US

Funding

TRAINING PROGRAM IN SIGNAL TRANSDUCTION AND CANCERT32CA070085 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1997 to 2026
$5.7M
SV40 Small-t Antigen and Human Cell TransformationR01CA021327 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RUNDELL, M KATHLEEN · 1985 to 2006
$1.8M
NCI NIH HHS CA 21327NCI NIH HHS R01 CA021327NCI NIH HHS T32 CA070085NCI NIH HHS T32 CA 70085
6 · The paper itself

Abstract

Three simian virus 40 (SV40) reporter viruses were constructed in this study. One expresses the green fluorescent protein (GFP) as a fusion protein with the first exon of large-T (LT) antigen and is useful for live-cell imaging. A second reporter virus has a FLAG epitope tag at the C-terminus of large-T antigen (vC-LT(FLAG)), and a third has the FLAG tag at the N-terminus of LT (vN-LT(FLAG)). The vC-LT(FLAG) construct grows to titers near those of wild-type (WT) virus and functions well as a reporter virus for SV40 infection. The vN-LT(FLAG) construct, while viable, has a defect in the production and spread of infectious particles. All three viruses are useful in detecting superinfecting virus in cells in which nuclear LT is already present, such as persistently infected human mesothelial cells.

Indexed as

Genes, ReporterAnimalsEpitopesGreen Fluorescent ProteinsHumansMicroscopy, FluorescenceOligopeptidesPeptidesSimian virus 40Viral Structural ProteinsEpitopesFLAG peptideGreen Fluorescent ProteinsOligopeptidesPeptidesViral Structural Proteins

Identifiers

PMID18403028
PMCPMC2440643
OpenAlexW2037334252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.