ArticleBMC immunology2008
Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva.
Article in BMC immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- PpSP32, the Phlebotomus papatasi immunodominant salivary protein, exerts immunomodulatory effects on human monocytes, macrophages, and lymphocytes.Parasites & vectors · 2023Article
- Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function.PLoS neglected tropical diseases · 2021Article
- Improving the methods for isolation of monocyte and establishing macrophage cell culture in caprine model.Cytotechnology · 2016Article
- Are Neutrophil Extracellular Traps Playing a Role in the Parasite Control in Active American Tegumentary Leishmaniasis Lesions?PloS one · 2015Article
- Sand-fly saliva-leishmania-man: the trigger trio.Frontiers in immunology · 2013Review
- The Trypanosoma brucei gambiense secretome impairs lipopolysaccharide-induced maturation, cytokine production, and allostimulatory capacity of dendritic cells.Infection and immunity · 2013Article
- The immunobiology of Leishmania braziliensis infection.Frontiers in immunology · 2012Article
- The immune response to sand fly salivary proteins and its influence on leishmania immunity.Frontiers in immunology · 2012Article
- Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis.PLoS neglected tropical diseases · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSand fly saliva contains potent and complex pharmacologic molecules that are able to modulate the host's hemostatic, inflammatory, and immune systems. In this study, we evaluated the effects of salivary gland sonicate (SGS) of Lutzomyia intermedia, the natural vector of Leishmania braziliensis, on monocytes obtained from the peripheral blood mononuclear cells (PBMC) of healthy volunteers. We investigated the effects of sand fly saliva on cytokine production and surface molecule expression of LPS-stimulated human monocytes uninfected or infected with L. braziliensis.
resultsPre-treatment of non-infected human monocytes with L. intermedia SGS followed by LPS-stimulation led to a significant decrease in IL-10 production accompanied by a significant increase in CD86, CD80, and HLA-DR expression. Pre-treatment with SGS followed by LPS stimulation and L. braziliensis infection led to a significant increase in TNF-alpha, IL-6, and IL-8 production without significant alterations in co-stimulatory molecule expression. However, pre-treatment with L. intermedia SGS did not result in significant changes in the infection rate of human monocytes.
conclusionOur data indicate that L. intermedia saliva is able to modulate monocyte response, and, although this modulation is dissociated from enhanced infection with L. braziliensis, it may be associated with successful parasitism.
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