ArticleVirus genes2008
Complete genome sequence of attenuated low-temperature Thiverval strain of classical swine fever virus.
Article in Virus genes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Pathogenicity of a novel classical swine fever LOM vaccine-derived virus isolated on Jeju Island, South Korea.Veterinary medicine and science · 2022Article
- Characterization of monoclonal antibodies that specifically differentiate field isolates from vaccine strains of classical swine fever virus.Frontiers in immunology · 2022Article
- A Polyuridine Insertion in the 3' Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets.Journal of virology · 2020Article
- Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs.Veterinary research · 2015Article
- Postnatal persistent infection with classical Swine Fever virus and its immunological implications.PloS one · 2015Article
- Time-calibrated phylogenomics of the classical swine fever viruses: genome-wide bayesian coalescent approach.PloS one · 2015Article
- Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus.RNA biology · 2012Article
- Clustering of classical swine fever virus isolates by codon pair bias.BMC research notes · 2011Article
- Analysis of synonymous codon usage in classical swine fever virus.Virus genes · 2009Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Thiverval vaccine strain of classical swine fever virus (CSFV) was derived from virulent Alfort strain through the serial passages in cells at 29-30 degrees C. In this study, we determined the complete genome sequence of this strain and found that its genome contains one open reading frame (ORF) that encodes a polyprotein with 3,898 amino acids. The 5'-UTR of Thiverval is 373 nt long with only one mutation at position 220. In contrast, the length of 3'-UTR is highly heterogeneous ranging from 233 to 259 bp. The heterogeneity of length of the 3'-UTR was due to an insertion of a variable length of T-rich sequence ranging from 6 to 32 nt. The insertion may change the structure and free energy of the 3'-UTR, resulting in a destabilization of the 3'-UTR. Sequence alignment of Thiverval and other CSFV strains showed 85.2-99.6% identities at the nucleotide level and 92.5-99.5% at the amino acid level. The phylogenetic tree analysis of the complete ORF, partial region of E2, and NS5B suggests that the CSFV Thiverval strain belongs to genetic group 1 and subgroup 1.1. The results from this study provide insight into the molecular mechanism of the attenuation of Thiverval vaccine strain.
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