ArticleJournal of molecular evolution2008
An extensive study of mutation and selection on the wobble nucleotide in tRNA anticodons in fungal mitochondrial genomes.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Genomic factors shaping codon usage across the Saccharomycotina subphylum.G3 (Bethesda, Md.) · 2024Article
- Differential Selection for Translation Efficiency Shapes Translation Machineries in Bacterial Species.Microorganisms · 2024Article
- Evolution and codon usage bias of mitochondrial and nuclear genomes in Aspergillus section Flavi.G3 (Bethesda, Md.) · 2023Article
- An improved estimation of tRNA expression to better elucidate the coevolution between tRNA abundance and codon usage in bacteria.Scientific reports · 2019Article
- Three new Diplozoidae mitogenomes expose unusual compositional biases within the Monogenea class: implications for phylogenetic studies.BMC evolutionary biology · 2018Article
- Coevolution between Stop Codon Usage and Release Factors in Bacterial Species.Molecular biology and evolution · 2016Article
- Differential codon adaptation between dsDNA and ssDNA phages in Escherichia coli.Molecular biology and evolution · 2014Article
- The effect of mutation and selection on codon adaptation in Escherichia coli bacteriophage.Genetics · 2014Article
- Mutation and selection cause codon usage and bias in mitochondrial genomes of ribbon worms (Nemertea).PloS one · 2014Article
- DAMBE5: a comprehensive software package for data analysis in molecular biology and evolution.Molecular biology and evolution · 2013Article
- Article
- Base-pairing versatility determines wobble sites in tRNA anticodons of vertebrate mitogenomes.PloS one · 2012Article
- The enigmatic mitochondrial genome of Rhabdopleura compacta (Pterobranchia) reveals insights into selection of an efficient tRNA system and supports monophyly of Ambulacraria.BMC evolutionary biology · 2011Article
- Mutation and selection on the wobble nucleotide in tRNA anticodons in marine bivalve mitochondrial genomes.PloS one · 2011Article
- The cost of wobble translation in fungal mitochondrial genomes: integration of two traditional hypotheses.BMC evolutionary biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two alternative hypotheses aim to predict the wobble nucleotide of tRNA anticodons in mitochondrion. The codon-anticodon adaptation hypothesis predicts that the wobble nucleotide of tRNA anticodon should evolve toward maximizing the Watson-Crick base pairing with the most frequently used codon within each synonymous codon family. In contrast, the wobble versatility hypothesis argues that the nucleotide at the wobble site should be occupied by a nucleotide most versatile in wobble pairing, i.e., the wobble site of the tRNA anticodon should be G for NNY codon families and U for NNR and NNN codon families (where Y stands for C or U, R for A or G, and N for any nucleotide). We examined codon usage and anticodon wobble sites in 36 fungal genomes to evaluate these two alternative hypotheses and identify exceptional cases that deserve new explanations. While the wobble versatility hypothesis is generally supported, there are interesting exceptions involving tRNA(Arg) translating the CGN codon family, tRNA(Trp) translating the UGR codon family, and tRNA(Met) translating the AUR codon family. Our results suggest that the potential to suppress stop codons, the historical inertia, and the conflict between translation initiation and elongation can all contribute to determining the wobble nucleotide of tRNA anticodons.
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