ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2008
Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.
- Fiber intake and laxation in people with normal bowel function: a systematic review.The American journal of clinical nutrition · 2026Pooled it
- Trial
- Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut-on-a-Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomimetic villi-crypt scaffold-on-chip with tunable mechanical properties for intestinal epithelium modeling.Materials today. Bio · 2026Article
- A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem.Advanced healthcare materials · 2026Article
- Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions.PLoS biology · 2026Article
- Reducing the weaning impact in piglets with dietary fiber: the role of milled almond shells compared to wheat bran.Journal of animal science · 2026Article
- Bubble-mediated hydrogen degassing in the rumen: a theoretical hypothesis with potential implications for methane mitigation.Frontiers in microbiology · 2026Article
- Hydrogel-based experimental models of the gastrointestinal tract.Microbiome · 2025Review
- Flow-induced mechano-modulation of intestinal permeability on chip.Materials today. Bio · 2025Article
- Small Intestine on a Chip Demonstrates Physiologic Mucus Secretion in the Presence of Lacticaseibacillus rhamnosus Biofilm.Biotechnology and bioengineering · 2025Article
- Dynamics of Spatial Organization of Bacterial Communities in a Tunable Flow Gut Microbiome-on-a-Chip.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nutrient digestion efficiency: a comparison between broiler chickens and growing pigs fed maize, barley and oats-based diets with an emphasis on starch.The British journal of nutrition · 2025Article
- A Pumpless, High-Throughput Microphysiological System to Mimic Enteric Innervation of Duodenal Epithelium and the Impact on Barrier Function.Advanced functional materials · 2024Article
- Detailed Analysis of Prebiotic Fructo- and Galacto-Oligosaccharides in the Human Small Intestine.Journal of agricultural and food chemistry · 2024Article
- Research progress on cottonseed meal as a protein source in pig nutrition: An updated review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Dissecting Gut-Microbial Community Interactions using a Gut Microbiome-on-a-Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Response of cells and tissues to shear stress.Journal of cell science · 2023Review
- Endogenous mucin conveyed to the mucosa with microbes can assure lumen fermentation and large intestinal security-swine versus fowl.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- An Engineered Living Intestinal Muscle Patch Produces Macroscopic Contractions that can Mix and Break Down Artificial Intestinal Contents.Advanced materials (Deerfield Beach, Fla.) · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physical properties of digesta may influence mixing, efficiency of digestion, and absorption within the lumen of the intestine. We review how the physical properties of digesta change during transit through the various segments of the intestine, and how their influence on flow and mixing may be modulated by peristaltic activity. We examine how, in more fluid digesta, the solid and liquid phases interact to influence flow and mixing. Similarly, how in viscid digesta, shear strength, plasticity and elasticity of contained particulate material may influence the permeation of the fluid phase and secretions into and out of the digesta bolus. The manner in which the solid and liquid phases of digesta interact in a partly gaseous environment, such as the lower bowel, to influence bolus cohesion is also examined. Those mechanisms that promote the formation of a less viscous layer at the mucosal interface to promote plug flow are reviewed, and their effect on the efficiency of mixing and digestion discussed. It is recommended that in any future work investigating the character of mixing in the intestine, a wider range of appropriate digesta properties be measured and that, in investigations of intestinal movement, perfusates with similar characteristics to digesta be used.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.