ArticleMolecular and cellular biochemistry2008
Influence of gender and oral contraceptives intake on innate and inflammatory response. Role of neuroendocrine factors.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- TLR4-mediated blunting of inflammatory responses to eccentric exercise in young women.Mediators of inflammation · 2014Trial
- The effect of hormone therapy and tibolone on serum CD40L and ADAM-8 in healthy post-menopausal women.Journal of endocrinological investigation · 2010Trial
- Comparison of the cytokine responses to acute strength exercise between oral contraceptive users and naturally cycling women.European journal of applied physiology · 2024Article
- Article
- A Single Bout of Fatiguing Aerobic Exercise Induces Similar Pronounced Immunological Responses in Both Sexes.Frontiers in physiology · 2022Article
- Considerations for Sex-Cognizant Research in Exercise Biology and Medicine.Frontiers in sports and active living · 2022Review
- Sex-specific alterations in blood-borne factors in physically inactive individuals are detrimental to endothelial cell functions.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Circulating Inflammatory Biomarkers and Endocrine Responses to Exercise in Female Soccer Players.Journal of human kinetics · 2020Article
- Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games.Frontiers in physiology · 2020Article
- Role of 72-kDa Heat Shock Protein in Heat-stimulated Regeneration of Injured Muscle in Rat.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Oral Contraceptives and Neutropenia: A Population-Based Cohort Study.Clinical drug investigation · 2019Article
- Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.Cell reports · 2019Article
- Moxibustion Reduces Inflammatory Response in the Hippocampus of a Chronic Exercise-Induced Fatigue Rat.Frontiers in integrative neuroscience · 2019Article
- Immune Response in Women during Exercise in the Heat: A Spotlight on Oral Contraception.Journal of sports science & medicine · 2018Article
- Influence of sex on cytokines, heat shock protein and oxidative stress markers in response to an acute total body resistance exercise protocol.Journal of exercise science and fitness · 2015Article
- Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice.Neuroscience · 2013Article
- Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain.American journal of physiology. Endocrinology and metabolism · 2013Article
- Article
- Lessons learned from phagocytic function studies in a large cohort of patients with recurrent infections.Journal of clinical immunology · 2012Article
- Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present work was to determine differences between young men (M), and women in the follicular phase (W) and women taking oral contraceptives containing ethinylestradiol (CW) in the phagocytic process of neutrophils (chemotaxis, phagocytosis and microbicide capacity), in the serum concentrations of cytokines both pro-inflammatory (IFNgamma, TNFalpha, IL-12, IL-6, IL-8) and anti-inflammatory ones (IL-10 and IL-13), and in neuroendocrine factors with immunomodulatory capacity (estradiol, prolactin, cortisol, catecolamines and 72 kDa heat shock proteins, Hsp72). Men showed a lower phagocytosis and microbicide capacity than women, and less serum concentrations of the pro-inflammatory cytokines IL-6 and IL-8. CW neutrophils also showed a lower phagocytic capacity than W neutrophils, together with less serum IL-8 concentration. CW showed the highest serum concentration of IL-13. However, no statistical changes were observed in the pro-inflammatory cytokines: INF-gamma, TNF-alpha, IL-12 and in the anti-inflammatory cytokine IL-10. The greater anti-inflammatory status in CW than in W was parallel with lower concentrations of oestrogens. Cortisol, prolactin, and the extracellular Hsp72 seem to be involved in the gender- and contraceptives-induced differences in the inflammatory response. While cortisol (in general an immunosuppressive hormone) showed the highest values in CW, prolactin and Hsp72 (an immunopermissive factors) showed the lowest values in CW and M. Less clear is the participation of catecholamines in the gender-inflammatory differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.