ArticleExperimental diabetes research2008
AGEs and glucose levels modulate type I and III procollagen mRNA synthesis in dermal fibroblasts cells culture.
Article in Experimental diabetes research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
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- Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers.Biomedicines · 2020Review
- Cardiac Glucolipotoxicity and Cardiovascular Outcomes.Medicina (Kaunas, Lithuania) · 2018Review
- Proteomic and immunochemical approaches to understanding the glycation behaviour of the casein and β-lactoglobulin fractions of flavoured drinks under UHT processing conditions.Scientific reports · 2018Article
- Fluvastatin inhibits advanced glycation end products-induced proliferation, migration, and extracellular matrix accumulation in vascular smooth muscle cells by targeting connective tissue growth factor.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Advanced glycation end products impair NLRP3 inflammasome-mediated innate immune responses in macrophages.The Journal of biological chemistry · 2017Article
- Disparate response of articular- and auricular-derived chondrocytes to oxygen tension.Connective tissue research · 2016Article
- Glucotoxicity Induced Oxidative Stress and Inflammation In Vivo and In Vitro in Psammomys obesus: Involvement of Aqueous Extract of Brassica rapa rapifera.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Changes in biological behaviors of rat dermal fibroblasts induced by high expression of MMP9.World journal of emergency medicine · 2014Article
- The biological behaviors of rat dermal fibroblasts can be inhibited by high levels of MMP9.Experimental diabetes research · 2012Article
- AGE-BSA down-regulates endothelial connexin43 gap junctions.BMC cell biology · 2011Article
- Evaluation of glycemic and lipid profile of offspring of diabetic Wistar rats treated with Malpighia emarginata juice.Experimental diabetes research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the dermis, fibroblasts play an important role in the turnover of the dermal extracellular matrix. Collagen I and III, the most important dermal proteins of the extracellular matrix, are progressively altered during ageing and diabetes. For mimicking diabetic conditions, the cultured human dermal fibroblasts were incubated with increasing amounts of AGE-modified BSA and D-glucose for 24 hours. The expression of procollagen alpha2(I) and procollagen alpha1(III) mRNA was analyzed by quantitative real-time PCR. Our data revealed that the treatment of fibroblasts with AGE-modified BSA upregulated the expression of procollagen alpha2(I) and procollagen alpha1(III) mRNA in a dose-dependent manner. High glucose levels mildly induced a profibrogenic pattern, increasing the procollagen alpha2(I) mRNA expression whereas there was a downregulation tendency of procollagen alpha1(III) mRNA.
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