ArticleJournal of biomedicine & biotechnology2008
Protein alterations in infiltrating ductal carcinomas of the breast as detected by nonequilibrium pH gradient electrophoresis and mass spectrometry.
Article in Journal of biomedicine & biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer.World journal of clinical oncology · 2024Article
- Review
- Potential new biomarkers for endometrial cancer.Cancer cell international · 2019Article
- Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer.British journal of cancer · 2015Article
- Identification of pancreatic cancer-associated tumor antigen from HSP-enriched tumor lysate-pulsed human dendritic cells.Yonsei medical journal · 2014Article
- Implications of functional proteomics in breast cancer.The oncologist · 2014Review
- Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model.Journal of the National Cancer Institute · 2013Article
- Life stage differences in mammary gland gene expression profile in non-human primates.Breast cancer research and treatment · 2012Article
- Proteomic studies in breast cancer (Review).Oncology letters · 2012Article
- Comparison of protein expression profiles of different stages of lymph nodes metastasis in breast cancer.International journal of biological sciences · 2012Article
- Breast cancer proteomics: a review for clinicians.Journal of cancer research and clinical oncology · 2011Review
- The application of SELDI-TOF-MS in clinical diagnosis of cancers.Journal of biomedicine & biotechnology · 2011Review
- Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins.Cancer genomics & proteomicsArticle
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Improvement of breast-cancer detection through the identification of potential cancer biomarkers is considered as a promising strategy for effective assessment of the disease. The current study has used nonequilibrium pH gradient electrophoresis with subsequent analysis by mass spectrometry to identify protein alterations in invasive ductal carcinomas of the breast from Tunisian women. We have identified multiple protein alterations in tumor tissues that were picked, processed, and unambiguously assigned identities by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF). The proteins identified span a wide range of functions and are believed to have potential clinical applications as cancer biomarkers. They include glycolytic enzymes, molecular chaperones, cytoskeletal-related proteins, antioxydant enzymes, and immunologic related proteins. Among these proteins, enolase 1, phosphoglycerate kinase 1, deoxyhemoglobin, Mn-superoxyde dismutase, alpha-B-crystallin, HSP27, Raf kinase inhibitor protein, heterogeneous nuclear ribonucleoprotein A2/B1, cofilin 1, and peptidylprolyl isomerase A were overexpressed in tumors compared with normal tissues. In contrast, the IGHG1 protein, the complement C3 component C3c, which are two newly identified protein markers, were downregulated in IDCA tissues.
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