ArticleJournal of endocrinological investigation2008
Diagnostic and prognostic implications of the World Health Organization classification of neuroendocrine tumors.
Article in Journal of endocrinological investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: the Papanicolaou Society of Cytopathology guidelines for pancreatobiliary cytology.Diagnostic cytopathology · 2014Guideline
- Anesthetic Management of Emergency Insulinoma Resection: Case Report and Review of Literature.Cureus · 2023Article
- The "chameleon" sellar lesions: a case report of unexpected sellar lesions.Frontiers in neurology · 2023Article
- Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update.World journal of clinical cases · 2022Review
- Primary renal small cell carcinoma: A case report.World journal of clinical cases · 2022Article
- Primary Intracranial Neuroendocrine Tumor of the Skull Base Complicated with Tension Pneumocephalus after Radiotherapy.NMC case report journal · 2021Article
- Primary pituitary neuroendocrine tumor: Case report and literature review.Surgical neurology international · 2017Article
- The ENETS/WHO grading system for neuroendocrine neoplasms of the gastroenteropancreatic system: a review of the current state, limitations and proposals for modifications.International journal of endocrine oncology · 2016Article
- Primary intracranial neuroendocrine tumor with ectopic adrenocorticotropic hormone syndrome: A rare and complicated case report and literature review.Molecular and clinical oncology · 2016Article
- Primary intracranial neuroendocrine tumor: two case reports.World journal of surgical oncology · 2016Article
- Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.Diagnostic pathology · 2014Article
- Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: The Papanicolaou Society of Cytopathology Guidelines.CytoJournal · 2014Article
- Distribution, incidence, and prognosis in neuroendocrine tumors: a population based study from a cancer registry.Pathology oncology research : POR · 2011Article
- Partitioning of bronchopulmonary carcinoids in two different prognostic categories by ki-67 score.Frontiers in endocrinology · 2011Article
- Incidence, survival, and prevalence of neuroendocrine tumors versus neuroblastoma in children and young adults: nine standard SEER registries, 1975-2006.Pediatric blood & cancer · 2011Article
- Squamous cell carcinoma and neuroendocrine carcinoma colliding in the esophagus.Clinics (Sao Paulo, Brazil) · 2010Article
- Gastric carcinoids: between underestimation and overtreatment.World journal of gastroenterology · 2009Article
- Article
- Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining.Endocrine pathology · 2008Review
- Neuroendocrine tumors (NETs) - experience of a single Center.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroendocrine differentiation of tumors is often difficult to establish. In the same manner, the evaluation of the prognostic role of neuroendocrine differentiation may constitute a relevant clinical problem. Although different classifications are used for neuroendocrine tumors (NET) of different origin, the last World Health Organization (WHO) classification of NET, originally proposed for gastroenteropancreatic tumors, has proved to be a practical tool to allow pathologists to uniform the diagnoses and re-classify these tumors into 3 main categories.
aimThe present study was carried out in order to evaluate diagnostic and prognostic implications of NET reclassification according to the last WHO classification of NET. MATERIALS AND
methodsThirty-one tumors with an initial diagnosis referable to a NET achieved before 1999 were independently evaluated by 3 pathologists on the basis of the 2000 WHO classification of NET. Immunohistochemistry for panneuroendocrine markers and Ki-67 was also performed in all cases.
resultsTwelve, 14, and 4 tumors were respectively reclassified as well-differentiated NET, well-differentiated neuroendocrine carcinoma and poorly differentiated neuroendocrine carcinoma; 1 tumor was reclassified as mixed endocrine-exocrine tumor. Two or more neuroendocrine markers were expressed in all NET regardless of histotype, differentiation degree, and site of primary tumor. After revision, 10 of the 31 tumors under study (32%) changed histo-prognostic category when compared to the initial diagnosis. Ki-67 score was the best predictor of survival at the multivariate analysis.
conclusionThe WHO classification is suitable to accurately reclassify tumors with an initial diagnosis referable to a NET and to separate these tumors in 3 well-distinct histo-prognostic categories with relevant clinical implications. Ki-67 score seems to be a better predictor of survival than the degree of differentiation.
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