ArticleProceedings of the National Academy of Sciences of the United States of America2008
Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at "Evolution Canyon," Israel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Wanted: A population genetic theory of biological noise regulation.PLoS genetics · 2026Article
- Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026Review
- Yeast mutation rates in alternative carbon sources reflect the influence of reactive oxygen species.microPublication biology · 2025Article
- Distribution and Environmental Drivers of Fungal Denitrifiers in Global Soils.Microbiology spectrum · 2023Article
- Genetic Biodiversity and Posttranslational Modifications of Protease Serine Endopeptidase in Different Strains ofBioMed research international · 2023Article
- Recent insights into the evolution of mutation rates in yeast.Current opinion in genetics & development · 2022Review
- Beneficial and pathogenic plant-microbe interactions during flooding stress.Plant, cell & environment · 2022Review
- A Nuclei-Based Conceptual Model of (Eco)evolutionary Dynamics in Fungal Heterokaryons.Frontiers in microbiology · 2022Article
- The Destructive Fungal PathogenPathogens (Basel, Switzerland) · 2020Review
- Review
- Temperature effects on life-history trade-offs, germline maintenance and mutation rate under simulated climate warming.Proceedings. Biological sciences · 2017Article
- Whole genome resequencing of Botrytis cinerea isolates identifies high levels of standing diversity.Frontiers in microbiology · 2015Article
- Evidence for adaptive evolution of low-temperature stress response genes in a Pooideae grass ancestor.The New phytologist · 2013Article
- Evidence for elevated mutation rates in low-quality genotypes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- "Evolution Canyon," a potential microscale monitor of global warming across life.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Elastase Activity in Aspergillus fumigatus Can Arise by Random, Spontaneous Mutations.International journal of evolutionary biology · 2010Article
- Social interactions and distribution of Bacillus subtilis pherotypes at microscale.Journal of bacteriology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When various wild strains of Penicillium lanosum and Aspergillus niger were placed in the same mild laboratory environment, their frequencies of new spontaneous mutations were clearly related to whether they had been isolated from a region of high or low microclimatic stress. In the mild environment, the total frequencies of conidial color and morphological mutations in P. lanosum, summed over all relevant loci, ranged from 0.29% to 2.4% for six strains from the north-facing, less stressful "European" slope (ES/NFS) of "Evolution Canyon" I, compared with 6.5-11.6% for five strains from the south-facing "African" slope (AS/SFS), which is a much more stressful environment, being harsher, drier, more fluctuating in temperature, and receiving up to eight times more UV radiation than the opposite slope. The corresponding figures for A. niger were 0.42-1.50% for three strains from the ES/NFS and 2.3-4.9% for six strains from the AS/SFS. The more mutagenic environment of the AS/SFS than of the ES/NFS means that, in Evolution Canyon, the mutation frequency differences between the very stressful environment and the less stressful environment are probably even larger than the 4- and 6-fold differences found here in a mild laboratory environment. The evidence from these two filamentous fungi, which have no sexual cycle, is that there are inherited differences in spontaneous mutation rates according to the levels of stress in the environment, and this feature may well be adaptive. Evolution Canyon I is at Nahal Oren, Mount Carmel, Israel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.