ArticleClinical and vaccine immunology : CVI2008
Effects of antenatal and postnatal environments on CD4 T-cell responses to Mycobacterium bovis BCG in healthy infants in the Gambia.
Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Heterologous immunological effects of early BCG vaccination in low-birth-weight infants in Guinea-Bissau: a randomized-controlled trial.The Journal of infectious diseases · 2015Trial
- Factors That Influence the Immune Response to Vaccination.Clinical microbiology reviews · 2019Review
- What Have We Learnt about BCG Vaccination in the Last 20 Years?Frontiers in immunology · 2017Review
- Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal.The American journal of tropical medicine and hygiene · 2014Article
- Variation between Populations in the Innate Immune Response to Vaccine Adjuvants.Frontiers in immunology · 2013Article
- Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination.BMC infectious diseases · 2012Article
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- Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.The Journal of infectious diseases · 2009Article
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Authors and funding
11 authors.
Funding
Abstract
The Mycobacterium bovis BCG vaccine has a poor record of efficacy in low-income tropical settings. Against this background, we evaluated the immune response of infants to mycobacterial antigens over the 2 years following BCG vaccination at birth by measuring the gamma interferon (IFN-gamma), interleukin-2 (IL-2), and CD154 responses of CD4 T cells. Similar numbers of cells expressed IFN-gamma in infants, 4- to 5-year-old children, and adults, while CD154 was not expressed at comparable levels until the second year of infancy. The IL-2 response remained relatively low in infants, children, and adults but correlated negatively with mother's body mass index and was highest among infants born to Mandinka mothers. Similarly, infants born in the wet season had a stronger CD154 response than those born in the dry season throughout the 2 years of the study. We conclude that the prenatal and perinatal environments have a lasting effect on the response of infants to the BCG vaccine.
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