ArticleClinical and vaccine immunology : CVI2008
LruA and LruB antibodies in sera of humans with leptospiral uveitis.
Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Autoimmune Diseases Following Environmental Disasters: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Leptospirosis-associated meningitis in a patient with sjögren's syndrome: a case report.BMC infectious diseases · 2023Article
- A New Recombinant Multiepitope Chimeric Protein ofTropical medicine and infectious disease · 2022Article
- Extracellular Proteome Analysis Shows the Abundance of Histidine Kinase Sensor Protein, DNA Helicase, Putative Lipoprotein Containing Peptidase M75 Domain and Peptidase C39 Domain Protein inPathogens (Basel, Switzerland) · 2021Article
- Association Between Severity of Leptospirosis and Subsequent Major Autoimmune Diseases: A Nationwide Observational Cohort Study.Frontiers in immunology · 2021Article
- Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin.BMC infectious diseases · 2019Article
- Spirochetal Lipoproteins and Immune Evasion.Frontiers in immunology · 2017Review
- Pathogenic Leptospira interrogans exoproteins are primarily involved in heterotrophic processes.Infection and immunity · 2015Article
- Leptospiral pathogenomics.Pathogens (Basel, Switzerland) · 2014Review
- The Cross-Talk between Spirochetal Lipoproteins and Immunity.Frontiers in immunology · 2014Review
- Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI.Infection and immunity · 2013Article
- Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis.Clinical and vaccine immunology : CVI · 2012Article
- Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer-membrane protein OmpL32.Microbiology (Reading, England) · 2012Article
- Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity.PLoS neglected tropical diseases · 2012Article
- Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake.PloS one · 2011Article
- Cross-reactivity of antibodies against leptospiral recurrent uveitis-associated proteins A and B (LruA and LruB) with eye proteins.PLoS neglected tropical diseases · 2010Article
- Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.Nature reviews. Microbiology · 2009Review
- Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastin.The Journal of biological chemistry · 2009Article
- Ocular leptospirosis: a review of current state of art of a neglected disease.Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behçet's syndrome produced antibodies that cross-reacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.