ArticleBiophysical journal2008
Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Analysis of dim-light responses in rod and cone photoreceptors with altered calcium kinetics.Journal of mathematical biology · 2023Article
- Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure.eLife · 2023Article
- Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure.bioRxiv : the preprint server for biology · 2023Article
- Effects of cell size and bicarbonate on single photon response variability in retinal rods.Frontiers in molecular neuroscience · 2022Article
- Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.Frontiers in molecular neuroscience · 2022Article
- Article
- Article
- Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods.PloS one · 2019Article
- Sperm Sensory Signaling.Cold Spring Harbor perspectives in biology · 2017Review
- Origins of the phototransduction delay as inferred from stochastic and deterministic simulation of the amplification cascade.Molecular vision · 2017Article
- The phototransduction machinery in the rod outer segment has a strong efficacy gradient.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Protein and Signaling Networks in Vertebrate Photoreceptor Cells.Frontiers in molecular neuroscience · 2015Review
- cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses.Frontiers in molecular neuroscience · 2015Review
- High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor.The Journal of cell biology · 2014Article
- Approaches and tools for modeling signaling pathways and calcium dynamics in neurons.Journal of neuroscience methods · 2013Review
- Will the rod bend or break? Analyzing the structural resilience of cellular organelles.Biophysical journal · 2013Article
- Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes.Neuron · 2012Article
- Spatiotemporal cGMP dynamics in living mouse rods.Biophysical journal · 2012Article
- G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.Pharmacology & therapeutics · 2012Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The single photon response in vertebrate phototransduction is highly reproducible despite a number of random components of the activation cascade, including the random activation site, the random walk of an activated receptor, and its quenching in a random number of steps. Here we use a previously generated and tested spatiotemporal mathematical and computational model to identify possible mechanisms of variability reduction. The model permits one to separate the process into modules, and to analyze their impact separately. We show that the activation cascade is responsible for generation of variability, whereas diffusion of the second messengers is responsible for its suppression. Randomness of the activation site contributes at early times to the coefficient of variation of the photoresponse, whereas the Brownian path of a photoisomerized rhodopsin (Rh*) has a negligible effect. The major driver of variability is the turnoff mechanism of Rh*, which occurs essentially within the first 2-4 phosphorylated states of Rh*. Theoretically increasing the number of steps to quenching does not significantly decrease the corresponding coefficient of variation of the effector, in agreement with the biochemical limitations on the phosphorylated states of the receptor. Diffusion of the second messengers in the cytosol acts as a suppressor of the variability generated by the activation cascade. Calcium feedback has a negligible regulatory effect on the photocurrent variability. A comparative variability analysis has been conducted for the phototransduction in mouse and salamander, including a study of the effects of their anatomical differences such as incisures and photoreceptors geometry on variability generation and suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.