ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Neuronal Imaging at 8-Bit Depth to Combine High Spatial and High Temporal Resolution With Acquisition Rates Up To 40 kHz.Journal of biophotonics · 2025Article
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- Article
- Imaging membrane potential changes from dendritic spines using computer-generated holography.Neurophotonics · 2017Article
- Using Intrinsic Flavoprotein and NAD(P)H Imaging to Map Functional Circuitry in the Main Olfactory Bulb.PloS one · 2016Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines.Advances in experimental medicine and biology · 2015Review
- 3D-printer visualization of neuron models.Frontiers in neuroinformatics · 2015Article
- Fast state-space methods for inferring dendritic synaptic connectivity.Journal of computational neuroscience · 2014Article
- Cortical dendritic spine heads are not electrically isolated by the spine neck from membrane potential signals in parent dendrites.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Adaptive stimulus optimization for sensory systems neuroscience.Frontiers in neural circuits · 2013Review
- The periglomerular cell of the olfactory bulb and its role in controlling mitral cell spiking: a computational model.PloS one · 2013Article
- Optimal experimental design for sampling voltage on dendritic trees in the low-SNR regime.Journal of computational neuroscience · 2012Article
- Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study.The Journal of physiology · 2011Article
- A new look at state-space models for neural data.Journal of computational neuroscience · 2010Review
- Fast Kalman filtering on quasilinear dendritic trees.Journal of computational neuroscience · 2010Article
- Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Chemosensory responses to CO2 in multiple brain stem nuclei determined using a voltage-sensitive dye in brain slices from rats.Journal of neurophysiology · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The input-output transform performed by mitral cells, the principal projection neurons of the olfactory bulb, is one of the key factors in understanding olfaction. We used combined calcium and voltage imaging from the same neuron and computer modeling to investigate signal processing in the mitral cells, focusing on the glomerular dendritic tuft. The main finding was that the dendritic tuft functions as a single electrical compartment for subthreshold signals within the range of amplitudes detectable by voltage-sensitive dye recording. These evoked EPSPs had uniform characteristics throughout the glomerular tuft. The Ca(2+) transients associated with spatially uniform subthreshold synaptic potentials were comparable but not equal in amplitude in all regions. The average range of normalized amplitudes of the EPSP-driven Ca(2+) signals from different locations on dendritic branches in the glomerular tuft was relatively narrow and appeared to be independent of the dendritic surface-to-volume ratio. The computer simulations constrained by the imaging data indicated that a synchronized activation of approximately 100 synapses randomly distributed on tuft branches was sufficient to generate spatially homogenous EPSPs. This number of activated synapses is consistent with the data from anatomical studies. Furthermore, voltage attenuation of the EPSP along the primary dendrite at physiological temperature was weak compared with other cell types. In the model, weak attenuation of the EPSP along the primary dendrite could be accounted for by passive electrical properties of the mitral cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.